FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: The POUNDS LOST trial

Xiaomin Zhang, Qibin Qi, Cuilin Zhang, Frank B. Hu, Frank M. Sacks, Lu Qi

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was geno-typed in 742 obese adults who were randomly assigned to one of four diets differing in the proportions of fat, protein, and carbohydrate. Body composition and fat distribution were measured by dual-energy x-ray absorptiometry and computed tomography. We found significant modification effects for intervention varying in dietary protein on 2-year changes in fat-free mass, whole body total percentage of fat mass, total adipose tissue mass, visceral adipose tissue mass, and superficial adipose tissue mass (for all interactions, P < 0.05). Carriers of the risk allele had a greater reduction in weight, body composition, and fat distribution in response to a high-protein diet, whereas an opposite genetic effect was observed on changes in fat distribution in response to a low-protein diet. Likewise, significant interaction patterns also were observed at 6 months. Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902.

Original languageEnglish (US)
Pages (from-to)3005-3011
Number of pages7
JournalDiabetes
Volume61
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Reducing Diet
Body Fat Distribution
Body Composition
Fats
Genotype
Diet
Weight Loss
Adipose Tissue
Alleles
Protein-Restricted Diet
Proteins
Intra-Abdominal Fat
Dietary Proteins
Adiposity
Obesity
Tomography
Carbohydrates
X-Rays
Genes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets : The POUNDS LOST trial. / Zhang, Xiaomin; Qi, Qibin; Zhang, Cuilin; Hu, Frank B.; Sacks, Frank M.; Qi, Lu.

In: Diabetes, Vol. 61, No. 11, 11.2012, p. 3005-3011.

Research output: Contribution to journalArticle

Zhang, Xiaomin ; Qi, Qibin ; Zhang, Cuilin ; Hu, Frank B. ; Sacks, Frank M. ; Qi, Lu. / FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets : The POUNDS LOST trial. In: Diabetes. 2012 ; Vol. 61, No. 11. pp. 3005-3011.
@article{faee5dcdde2345f59a227c3747754e5e,
title = "FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: The POUNDS LOST trial",
abstract = "Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was geno-typed in 742 obese adults who were randomly assigned to one of four diets differing in the proportions of fat, protein, and carbohydrate. Body composition and fat distribution were measured by dual-energy x-ray absorptiometry and computed tomography. We found significant modification effects for intervention varying in dietary protein on 2-year changes in fat-free mass, whole body total percentage of fat mass, total adipose tissue mass, visceral adipose tissue mass, and superficial adipose tissue mass (for all interactions, P < 0.05). Carriers of the risk allele had a greater reduction in weight, body composition, and fat distribution in response to a high-protein diet, whereas an opposite genetic effect was observed on changes in fat distribution in response to a low-protein diet. Likewise, significant interaction patterns also were observed at 6 months. Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902.",
author = "Xiaomin Zhang and Qibin Qi and Cuilin Zhang and Hu, {Frank B.} and Sacks, {Frank M.} and Lu Qi",
year = "2012",
month = "11",
doi = "10.2337/db11-1799",
language = "English (US)",
volume = "61",
pages = "3005--3011",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "11",

}

TY - JOUR

T1 - FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets

T2 - The POUNDS LOST trial

AU - Zhang, Xiaomin

AU - Qi, Qibin

AU - Zhang, Cuilin

AU - Hu, Frank B.

AU - Sacks, Frank M.

AU - Qi, Lu

PY - 2012/11

Y1 - 2012/11

N2 - Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was geno-typed in 742 obese adults who were randomly assigned to one of four diets differing in the proportions of fat, protein, and carbohydrate. Body composition and fat distribution were measured by dual-energy x-ray absorptiometry and computed tomography. We found significant modification effects for intervention varying in dietary protein on 2-year changes in fat-free mass, whole body total percentage of fat mass, total adipose tissue mass, visceral adipose tissue mass, and superficial adipose tissue mass (for all interactions, P < 0.05). Carriers of the risk allele had a greater reduction in weight, body composition, and fat distribution in response to a high-protein diet, whereas an opposite genetic effect was observed on changes in fat distribution in response to a low-protein diet. Likewise, significant interaction patterns also were observed at 6 months. Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902.

AB - Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions. FTO rs1558902 was geno-typed in 742 obese adults who were randomly assigned to one of four diets differing in the proportions of fat, protein, and carbohydrate. Body composition and fat distribution were measured by dual-energy x-ray absorptiometry and computed tomography. We found significant modification effects for intervention varying in dietary protein on 2-year changes in fat-free mass, whole body total percentage of fat mass, total adipose tissue mass, visceral adipose tissue mass, and superficial adipose tissue mass (for all interactions, P < 0.05). Carriers of the risk allele had a greater reduction in weight, body composition, and fat distribution in response to a high-protein diet, whereas an opposite genetic effect was observed on changes in fat distribution in response to a low-protein diet. Likewise, significant interaction patterns also were observed at 6 months. Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902.

UR - http://www.scopus.com/inward/record.url?scp=84868029849&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868029849&partnerID=8YFLogxK

U2 - 10.2337/db11-1799

DO - 10.2337/db11-1799

M3 - Article

C2 - 22891219

AN - SCOPUS:84868029849

VL - 61

SP - 3005

EP - 3011

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 11

ER -