Fruits, vegetables and lung cancer: A pooled analysis of cohort studies

Stephanie A. Smith-Warner, Donna Spiegelman, Shiaw Shyuan Yaun, Demetrius Albanes, W. Lawrence Beeson, Piet A. Van Den Brandt, Diane Feskanich, Aaron R. Folsom, Gary E. Fraser, Jo L. Freudenheim, Edward Giovannucci, R. Alexandra Goldbohm, Saxon Graham, Lawrence H. Kushi, Anthony B. Miller, Pirjo Pietinen, Thomas E. Rohan, Frank E. Speizer, Walter C. Willett, David J. Hunter

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Inverse associations between fruit and vegetable consumption and lung cancer risk have been consistently reported. However, identifying the specific fruits and vegetables associated with lung cancer is difficult because the food groups and foods evaluated have varied across studies. We analyzed fruit and vegetable groups using standardized exposure and covariate definitions in 8 prospective studies. We combined study-specific relative risks (RRs) using a random effects model. In the pooled database, 3,206 incident lung cancer cases occurred among 430,281 women and men followed for up to 6-16 years across studies. Controlling for smoking habits and other lung cancer risk factors, a 16-23% reduction in lung cancer risk was observed for quintiles 2 through 5 vs. the lowest quintile of consumption for total fruits (RR = 0.77; 95% CI = 0.67-0.87 for quintile 5; p-value, test for trend < 0.001) and for total fruits and vegetables (RR = 0.79; 95% CI = 0.69-0.90; p-value, test for trend = 0.001). For the same comparison, the association was weaker for total vegetable consumption (RR = 0.88; 95% CI = 0.78-1.00; p-value, test for trend = 0.12). Associations were similar between never, past, and current smokers. These results suggest that elevated fruit and vegetable consumption is associated with a modest reduction in lung cancer risk, which is mostly attributable to fruit, not vegetable, intake. However, we cannot rule out the possibility that our results are due to residual confounding by smoking. The primary focus for reducing lung cancer incidence should continue to be smoking prevention and cessation.

Original languageEnglish (US)
Pages (from-to)1001-1011
Number of pages11
JournalInternational Journal of Cancer
Volume107
Issue number6
DOIs
StatePublished - Dec 20 2003

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Vegetables
Fruit
Lung Neoplasms
Cohort Studies
Smoking
Food
Smoking Cessation
Habits
Databases
Prospective Studies
Incidence

Keywords

  • Cohort studies
  • Fruit
  • Lung neoplasms
  • Pooling
  • Vegetables

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Smith-Warner, S. A., Spiegelman, D., Yaun, S. S., Albanes, D., Beeson, W. L., Van Den Brandt, P. A., ... Hunter, D. J. (2003). Fruits, vegetables and lung cancer: A pooled analysis of cohort studies. International Journal of Cancer, 107(6), 1001-1011. https://doi.org/10.1002/ijc.11490

Fruits, vegetables and lung cancer : A pooled analysis of cohort studies. / Smith-Warner, Stephanie A.; Spiegelman, Donna; Yaun, Shiaw Shyuan; Albanes, Demetrius; Beeson, W. Lawrence; Van Den Brandt, Piet A.; Feskanich, Diane; Folsom, Aaron R.; Fraser, Gary E.; Freudenheim, Jo L.; Giovannucci, Edward; Goldbohm, R. Alexandra; Graham, Saxon; Kushi, Lawrence H.; Miller, Anthony B.; Pietinen, Pirjo; Rohan, Thomas E.; Speizer, Frank E.; Willett, Walter C.; Hunter, David J.

In: International Journal of Cancer, Vol. 107, No. 6, 20.12.2003, p. 1001-1011.

Research output: Contribution to journalArticle

Smith-Warner, SA, Spiegelman, D, Yaun, SS, Albanes, D, Beeson, WL, Van Den Brandt, PA, Feskanich, D, Folsom, AR, Fraser, GE, Freudenheim, JL, Giovannucci, E, Goldbohm, RA, Graham, S, Kushi, LH, Miller, AB, Pietinen, P, Rohan, TE, Speizer, FE, Willett, WC & Hunter, DJ 2003, 'Fruits, vegetables and lung cancer: A pooled analysis of cohort studies', International Journal of Cancer, vol. 107, no. 6, pp. 1001-1011. https://doi.org/10.1002/ijc.11490
Smith-Warner SA, Spiegelman D, Yaun SS, Albanes D, Beeson WL, Van Den Brandt PA et al. Fruits, vegetables and lung cancer: A pooled analysis of cohort studies. International Journal of Cancer. 2003 Dec 20;107(6):1001-1011. https://doi.org/10.1002/ijc.11490
Smith-Warner, Stephanie A. ; Spiegelman, Donna ; Yaun, Shiaw Shyuan ; Albanes, Demetrius ; Beeson, W. Lawrence ; Van Den Brandt, Piet A. ; Feskanich, Diane ; Folsom, Aaron R. ; Fraser, Gary E. ; Freudenheim, Jo L. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Graham, Saxon ; Kushi, Lawrence H. ; Miller, Anthony B. ; Pietinen, Pirjo ; Rohan, Thomas E. ; Speizer, Frank E. ; Willett, Walter C. ; Hunter, David J. / Fruits, vegetables and lung cancer : A pooled analysis of cohort studies. In: International Journal of Cancer. 2003 ; Vol. 107, No. 6. pp. 1001-1011.
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