Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation

Juan M. Fernández, Marzo E. Da Silva-Grigoletto, Juan A. Ruano-Ruíz, Javier Caballero-Villarraso, Rafael Moreno-Luna, Isaac Túnez-Fiñana, Inmaculada Tasset, Pablo Pérez-Martínez, José López-Miranda, Francisco Pérez-Jiménez

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The metabolic response when aerobic exercise is performed after the ingestion of glucose plus fructose is unclear. In the present study, we administered two beverages containing GluF (glucose + fructose) or Glu (glucose alone) in a randomized cross-over design to 20 healthy aerobically trained volunteers to compare the hormonal and lipid responses provoked during aerobic exercise and the recovery phase. After ingesting the beverages and a 15-min resting period, volunteers performed 30 min of moderate aerobic exercise. Urinary and blood samples were taken at baseline (t-15), during the exercise (t0, t15 and t30) and during the recovery phase (t45, t75 and t105). Plasma insulin concentrations were higher halfway through the exercise period and during acute recuperation (t15 and t75; P < 0.05) following ingestion of GluF than after Glu alone, without any differences between the effects of either intervention on plasma glucose concentrations. Towards the end of the exercise period, urinary catecholamine concentrations were lower following GluF (t45; P < 0.05). Plasma triacylglycerol (triglyceride) concentrations were higher after the ingestion of GluF compared with Glu (t15, t30, t45 and t105; P < 0.05). Furthermore, with GluF, we observed higher levels of lipoperoxides (t15, t30, t45 and t105; P < 0.05) and oxidized LDL (low-density lipoprotein; t30, P < 0.05) compared with after the ingestion of Glu alone. In conclusion, hormonal and lipid alterations are provoked during aerobic exercise and recovery by the addition of a dose of fructose to the pre-exercise ingestion of glucose.

Original languageEnglish (US)
Pages (from-to)137-145
Number of pages9
JournalClinical Science
Volume116
Issue number2
DOIs
StatePublished - Jan 2009
Externally publishedYes

Fingerprint

Fructose
Lipid Metabolism
Exercise
Glucose
Eating
Beverages
Volunteers
Triglycerides
Lipids
Lipid Peroxides
Cross-Over Studies
Catecholamines
Insulin

Keywords

  • Carbohydrate supplementation
  • Exercise
  • Fructose
  • Glucose
  • Hypertriacylglycerolaemia
  • Lipid metabolism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fernández, J. M., Da Silva-Grigoletto, M. E., Ruano-Ruíz, J. A., Caballero-Villarraso, J., Moreno-Luna, R., Túnez-Fiñana, I., ... Pérez-Jiménez, F. (2009). Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation. Clinical Science, 116(2), 137-145. https://doi.org/10.1042/CS20080120

Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation. / Fernández, Juan M.; Da Silva-Grigoletto, Marzo E.; Ruano-Ruíz, Juan A.; Caballero-Villarraso, Javier; Moreno-Luna, Rafael; Túnez-Fiñana, Isaac; Tasset, Inmaculada; Pérez-Martínez, Pablo; López-Miranda, José; Pérez-Jiménez, Francisco.

In: Clinical Science, Vol. 116, No. 2, 01.2009, p. 137-145.

Research output: Contribution to journalArticle

Fernández, JM, Da Silva-Grigoletto, ME, Ruano-Ruíz, JA, Caballero-Villarraso, J, Moreno-Luna, R, Túnez-Fiñana, I, Tasset, I, Pérez-Martínez, P, López-Miranda, J & Pérez-Jiménez, F 2009, 'Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation', Clinical Science, vol. 116, no. 2, pp. 137-145. https://doi.org/10.1042/CS20080120
Fernández JM, Da Silva-Grigoletto ME, Ruano-Ruíz JA, Caballero-Villarraso J, Moreno-Luna R, Túnez-Fiñana I et al. Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation. Clinical Science. 2009 Jan;116(2):137-145. https://doi.org/10.1042/CS20080120
Fernández, Juan M. ; Da Silva-Grigoletto, Marzo E. ; Ruano-Ruíz, Juan A. ; Caballero-Villarraso, Javier ; Moreno-Luna, Rafael ; Túnez-Fiñana, Isaac ; Tasset, Inmaculada ; Pérez-Martínez, Pablo ; López-Miranda, José ; Pérez-Jiménez, Francisco. / Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation. In: Clinical Science. 2009 ; Vol. 116, No. 2. pp. 137-145.
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