FRS2α-dependent cell fate transition during endocardial cushion morphogenesis

Dongying Chen, Xiaolong Zhu, Natalie Kofler, Yidong Wang, Bin Zhou, Michael Simons

Research output: Contribution to journalArticle

Abstract

FRS2α controls a two-phase cell fate transition of endocardial lineage during valve morphogenesis, from endocardial cells to cushion mesenchymal cells (endothelial-to-mesenchymal transition) and then to valve interstitial cells (terminal differentiation).

Original languageEnglish (US)
Pages (from-to)88-97
Number of pages10
JournalDevelopmental Biology
Volume458
Issue number1
DOIs
StatePublished - Feb 1 2020

Keywords

  • Cardiovascular development
  • Cell fate
  • EndMT
  • Endocardial cushion
  • Endothelial-to-mesenchymal transition
  • Valvulogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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