Abstract
FRS2α controls a two-phase cell fate transition of endocardial lineage during valve morphogenesis, from endocardial cells to cushion mesenchymal cells (endothelial-to-mesenchymal transition) and then to valve interstitial cells (terminal differentiation).
Original language | English (US) |
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Pages (from-to) | 88-97 |
Number of pages | 10 |
Journal | Developmental Biology |
Volume | 458 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2020 |
Keywords
- Cardiovascular development
- Cell fate
- EndMT
- Endocardial cushion
- Endothelial-to-mesenchymal transition
- Valvulogenesis
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology