Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses

M. Mehmet Haznedar, Francesca Roversi, Stefano Pallanti, Nicolo Baldini-Rossi, David B. Schnur, Elizabeth M. Licalzi, Cheuk Tang, Patrick R. Hof, Eric Hollander, Monte S. Buchsbaum

Research output: Contribution to journalArticle

164 Scopus citations

Abstract

Background: Neurons in the basal ganglia are connected to areas of prefrontal cerebral cortex involved in higher cognitive functions, and these connections occur primarily via the thalamus. In patients with bipolar disorder, regardless of age, neuroimaging studies have consistently reported an increased number of white matter hyperintensities, indicating possible alterations in striatum-thalamus and thalamus-prefrontal cortex connections. Methods: In the current study, we acquired high-resolution magnetic resonance imaging (MRI) and diffusion tensor (DT) scans of 40 patients with bipolar spectrum (BPS) illnesses (bipolar type I = 17, bipolar type II = 7, cyclothymia = 16) and 36 sex- and age-matched control subjects. Two researchers, without knowledge of diagnosis, outlined the caudate, putamen, and thalamus on contiguous axial MRI slices. We measured the volumes of the basal ganglia, thalamus, and gray/white matter of the frontal cortex. Results: Bipolar spectrum patients as a single group did not differ from control subjects in thalamus and the basal ganglia volumes, but the cyclothymia patients had reductions in the volumes of putamen and the thalamus compared with control subjects. The BPS patients had significantly reduced volume of the white and the gray matter of the frontal cortex. Furthermore, compared with control subjects, BPS patients as a group showed alterations in anisotropy of the internal capsule adjacent to the striatum and thalamus and the frontal white matter. Conclusions: Our findings indicate that BPS patients may have distinct anatomical alterations in brain structures involved in the regulation of mood and cognition, as well as alterations in these structures' connection to related brain areas.

Original languageEnglish (US)
Pages (from-to)733-742
Number of pages10
JournalBiological Psychiatry
Volume57
Issue number7
DOIs
StatePublished - Mar 15 2005
Externally publishedYes

Keywords

  • Bipolar disorder
  • Diffusion tensor
  • Prefrontal cortex
  • Striatum
  • Thalamus

ASJC Scopus subject areas

  • Biological Psychiatry

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    Haznedar, M. M., Roversi, F., Pallanti, S., Baldini-Rossi, N., Schnur, D. B., Licalzi, E. M., Tang, C., Hof, P. R., Hollander, E., & Buchsbaum, M. S. (2005). Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biological Psychiatry, 57(7), 733-742. https://doi.org/10.1016/j.biopsych.2005.01.002