TY - JOUR
T1 - From a common progenitor to distinct liver epithelial phenotypes
AU - Müsch, Anne
N1 - Funding Information:
I thank Win Arias, Lola Reid and the members of my laboratory for ongoing discussions on the topic, and Alex Treyer and David Cohen for comments on the manuscript. I apologize to all colleagues whose important contributions to liver architecture and polarity were not mentioned due to the restricted scope of this review. Work in my lab was funded by NIH RO1DK064842 and by Albert-Einstein College of Medicine .
Funding Information:
I thank Win Arias, Lola Reid and the members of my laboratory for ongoing discussions on the topic, and Alex Treyer and David Cohen for comments on the manuscript. I apologize to all colleagues whose important contributions to liver architecture and polarity were not mentioned due to the restricted scope of this review. Work in my lab was funded by NIH RO1DK064842 and by Albert-Einstein College of Medicine.
Publisher Copyright:
© 2018 Elsevier Ltd
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - The vertebrate liver presents a fascinating case study for how cell form is optimized for function. To execute its duties the liver assembles two distinct lumen-forming epithelial phenotypes: Firstly, cords with a branched, capillary-like luminal network formed between hepatocytes (bile canaliculi); and secondly, tubular ducts formed by biliary epithelial cells arranged around a central cavity and connected to the bile canaliculi. How these remarkably different epithelial polarity phenotypes are generated and joined into a contiguous luminal network are major unresolved questions. Recent studies have characterized the divergence of the two epithelial lineages from common progenitors, described the coordination of bile canaliculi formation with bile duct branching during biliary tree morphogenesis and implicated RhoA-dependent E-cadherin adhesion in the decision to polarize with hepatocytic or biliary phenotype.
AB - The vertebrate liver presents a fascinating case study for how cell form is optimized for function. To execute its duties the liver assembles two distinct lumen-forming epithelial phenotypes: Firstly, cords with a branched, capillary-like luminal network formed between hepatocytes (bile canaliculi); and secondly, tubular ducts formed by biliary epithelial cells arranged around a central cavity and connected to the bile canaliculi. How these remarkably different epithelial polarity phenotypes are generated and joined into a contiguous luminal network are major unresolved questions. Recent studies have characterized the divergence of the two epithelial lineages from common progenitors, described the coordination of bile canaliculi formation with bile duct branching during biliary tree morphogenesis and implicated RhoA-dependent E-cadherin adhesion in the decision to polarize with hepatocytic or biliary phenotype.
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U2 - 10.1016/j.ceb.2018.02.008
DO - 10.1016/j.ceb.2018.02.008
M3 - Review article
C2 - 29505983
AN - SCOPUS:85042686341
VL - 54
SP - 18
EP - 23
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -