From a common progenitor to distinct liver epithelial phenotypes

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The vertebrate liver presents a fascinating case study for how cell form is optimized for function. To execute its duties the liver assembles two distinct lumen-forming epithelial phenotypes: Firstly, cords with a branched, capillary-like luminal network formed between hepatocytes (bile canaliculi); and secondly, tubular ducts formed by biliary epithelial cells arranged around a central cavity and connected to the bile canaliculi. How these remarkably different epithelial polarity phenotypes are generated and joined into a contiguous luminal network are major unresolved questions. Recent studies have characterized the divergence of the two epithelial lineages from common progenitors, described the coordination of bile canaliculi formation with bile duct branching during biliary tree morphogenesis and implicated RhoA-dependent E-cadherin adhesion in the decision to polarize with hepatocytic or biliary phenotype.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume54
DOIs
StatePublished - Oct 1 2018

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Bile Canaliculi
Phenotype
Liver
Biliary Tract
Cadherins
Bile Ducts
Morphogenesis
Vertebrates
Hepatocytes
Epithelial Cells

ASJC Scopus subject areas

  • Cell Biology

Cite this

From a common progenitor to distinct liver epithelial phenotypes. / Muesch, Anne.

In: Current Opinion in Cell Biology, Vol. 54, 01.10.2018, p. 18-23.

Research output: Contribution to journalReview article

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