Frequent Met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis

Gromoslaw A. Smolen, Beth Muir, Gayatry Mohapatra, Anne Barmettler, Woo J. Kim, Miguel N. Rivera, Sara M. Haserlat, Ross A. Okimoto, Eunice Kwak, Sonika Dahiya, Judy E. Garber, Daphne W. Bell, Dennis C. Sgroi, Lynda Chin, Chu Xia Deng, Daniel A. Haber

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

In a screen for gene copy number alterations in mouse mammary tumors initiated by loss of the Brca1 and Trp53 genes, we observed that the majority (11 of 15; 73%) had high-level amplification of wild-type Met, encoding a growth factor receptor implicated in tumor progression. Met amplification was localized to unstable double minute chromosomes and was uniquely found in mouse breast tumors driven by loss of Brca1 and Trp53. Whereas analogous MET amplification was not found in human breast cancers, the identification of a dominant somatic genetic lesion in the Brca1/Trp53 mouse model suggests that recurrent secondary hits may also exist in BRCA1-initiated human breast cancer.

Original languageEnglish (US)
Pages (from-to)3452-3455
Number of pages4
JournalCancer research
Volume66
Issue number7
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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