Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney

Mark P. Schoenberg, P. Cairns, J. D. Brooks, F. F. Marshall, J. I. Epstein, W. B. Isaacs, D. Sidransky

Research output: Contribution to journalArticle

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Abstract

Collecting duct carcinoma (CDC) is a malignant renal neoplasm that is believed to arise from the epithelium of the ducts of Bellini in the distal nephron. These tumors are clinically aggressive and more often occur in a younger population than is typical of the more common clear cell renal carcinoma (RCC). Using highly informative polymorphic microsatellite markers on chromosome arms 3p, 5q, 6q, 8p, 9p, 9q, 11p, 13q, 17p, and 18q, we analyzed DNA from nonmalignant and tumor tissue in 6 cases of CDC. We found no evidence of 3p loss of heterozygosity (LOH) in these renal tumors by using multiple markers, a finding that distinguishes CDC from RCC in which 3p LOH has frequently been observed. We found LOH of 8p in 50% of the tumors examined; in addition, we observed LOH of 13q in 50% of the tumors studied. Interestingly, 8p LOH may be associated with high stage and poor clinical prognosis. These data suggest that the molecular events responsible for the development of CDC differ from those associated with the origin of RCC, and that tumor suppressor genes on 8p and 13q may be involved in the pathogenesis of CDC.

Original languageEnglish (US)
Pages (from-to)76-80
Number of pages5
JournalGenes Chromosomes and Cancer
Volume12
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

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Renal Cell Carcinoma
Loss of Heterozygosity
Chromosomes
Neoplasms
Carcinoma
Kidney
Kidney Neoplasms
Nephrons
Tumor Suppressor Genes
Microsatellite Repeats
Epithelium
DNA
Population

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Schoenberg, M. P., Cairns, P., Brooks, J. D., Marshall, F. F., Epstein, J. I., Isaacs, W. B., & Sidransky, D. (1995). Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. Genes Chromosomes and Cancer, 12(1), 76-80. https://doi.org/10.1002/gcc.2870120115

Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. / Schoenberg, Mark P.; Cairns, P.; Brooks, J. D.; Marshall, F. F.; Epstein, J. I.; Isaacs, W. B.; Sidransky, D.

In: Genes Chromosomes and Cancer, Vol. 12, No. 1, 1995, p. 76-80.

Research output: Contribution to journalArticle

Schoenberg, MP, Cairns, P, Brooks, JD, Marshall, FF, Epstein, JI, Isaacs, WB & Sidransky, D 1995, 'Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney', Genes Chromosomes and Cancer, vol. 12, no. 1, pp. 76-80. https://doi.org/10.1002/gcc.2870120115
Schoenberg, Mark P. ; Cairns, P. ; Brooks, J. D. ; Marshall, F. F. ; Epstein, J. I. ; Isaacs, W. B. ; Sidransky, D. / Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. In: Genes Chromosomes and Cancer. 1995 ; Vol. 12, No. 1. pp. 76-80.
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AU - Schoenberg, Mark P.

AU - Cairns, P.

AU - Brooks, J. D.

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AU - Epstein, J. I.

AU - Isaacs, W. B.

AU - Sidransky, D.

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N2 - Collecting duct carcinoma (CDC) is a malignant renal neoplasm that is believed to arise from the epithelium of the ducts of Bellini in the distal nephron. These tumors are clinically aggressive and more often occur in a younger population than is typical of the more common clear cell renal carcinoma (RCC). Using highly informative polymorphic microsatellite markers on chromosome arms 3p, 5q, 6q, 8p, 9p, 9q, 11p, 13q, 17p, and 18q, we analyzed DNA from nonmalignant and tumor tissue in 6 cases of CDC. We found no evidence of 3p loss of heterozygosity (LOH) in these renal tumors by using multiple markers, a finding that distinguishes CDC from RCC in which 3p LOH has frequently been observed. We found LOH of 8p in 50% of the tumors examined; in addition, we observed LOH of 13q in 50% of the tumors studied. Interestingly, 8p LOH may be associated with high stage and poor clinical prognosis. These data suggest that the molecular events responsible for the development of CDC differ from those associated with the origin of RCC, and that tumor suppressor genes on 8p and 13q may be involved in the pathogenesis of CDC.

AB - Collecting duct carcinoma (CDC) is a malignant renal neoplasm that is believed to arise from the epithelium of the ducts of Bellini in the distal nephron. These tumors are clinically aggressive and more often occur in a younger population than is typical of the more common clear cell renal carcinoma (RCC). Using highly informative polymorphic microsatellite markers on chromosome arms 3p, 5q, 6q, 8p, 9p, 9q, 11p, 13q, 17p, and 18q, we analyzed DNA from nonmalignant and tumor tissue in 6 cases of CDC. We found no evidence of 3p loss of heterozygosity (LOH) in these renal tumors by using multiple markers, a finding that distinguishes CDC from RCC in which 3p LOH has frequently been observed. We found LOH of 8p in 50% of the tumors examined; in addition, we observed LOH of 13q in 50% of the tumors studied. Interestingly, 8p LOH may be associated with high stage and poor clinical prognosis. These data suggest that the molecular events responsible for the development of CDC differ from those associated with the origin of RCC, and that tumor suppressor genes on 8p and 13q may be involved in the pathogenesis of CDC.

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