Frequency of severe renal artery stenosis in patients with severe thoracic aortic plaque

Harmony R. Reynolds, Paul A. Tunick, Ricardo J. Benenstein, Navin C. Nakra, Alan Shah, Daniel M. Spevack, Itzhak Kronzon

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Atherosclerotic renal artery stenosis (RAS) is an underdiagnosed disorder and a treatable etiology of hypertension and renal insufficiency. All patients were referred for a transesophageal echocardiogram for various indications. Abdominal ultrasound was performed in 69 patients, 43 with severe thoracic aortic plaque (≥4 mm) and 26 controls with no or mild plaque (≤2 mm). Severe RAS (≥60%) was defined as flow velocity ≥1.8 m/s and a renal:aortic ratio of ≥3.5. There were 8 cases of RAS (all severe) in the 43 patients with severe aortic plaque (19% vs 0% of controls; p = 0.02). Severe plaque (p = 0.02) and hypertension (p = 0.03) were correlated with RAS. On multivariate analysis, severe plaque (p = 0.017) and hypertension (p = 0.002) remained independently correlated with RAS. In a paired analysis, matched for age and gender (McNemar), severe plaque was significantly associated with RAS (p = 0.008). Severe thoracic aortic plaque is strongly associated with RAS, which is found in 19% of patients with severe plaque. Patients found to have severe aortic plaque on transesophageal echocardiography should be screened for RAS.

Original languageEnglish (US)
Pages (from-to)844-846
Number of pages3
JournalAmerican Journal of Cardiology
Issue number6
StatePublished - Sep 15 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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