Frequency of Atrial Arrhythmia in Hospitalized Patients With COVID-19

Hirad Yarmohammadi, John P. Morrow, Jose Dizon, Angelo Biviano, Frederick Ehlert, Deepak Saluja, Marc Waase, Pierre Elias, Timothy J. Poterucha, Jeremy Berman, Alexander Kushnir, Mark P. Abrams, Geoffrey A. Rubin, Stephanie Jou, Jessica Hennessey, Nir Uriel, Elaine Y. Wan, Hasan Garan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

There is growing evidence that COVID-19 can cause cardiovascular complications. However, there are limited data on the characteristics and importance of atrial arrhythmia (AA) in patients hospitalized with COVID-19. Data from 1,029 patients diagnosed with of COVID-19 and admitted to Columbia University Medical Center between March 1, 2020 and April 15, 2020 were analyzed. The diagnosis of AA was confirmed by 12 lead electrocardiographic recordings, 24-hour telemetry recordings and implantable device interrogations. Patients' history, biomarkers and hospital course were reviewed. Outcomes that were assessed were intubation, discharge and mortality. Of 1,029 patients reviewed, 82 (8%) were diagnosed with AA in whom 46 (56%) were new-onset AA 16 (20%) recurrent paroxysmal and 20 (24%) were chronic persistent AA. Sixty-five percent of the patients diagnosed with AA (n=53) died. Patients diagnosed with AA had significantly higher mortality compared with those without AA (65% vs 21%; p < 0.001). Predictors of mortality were older age (Odds Ratio (OR)=1.12, [95% Confidence Interval (CI), 1.04 to 1.22]); male gender (OR=6.4 [95% CI, 1.3 to 32]); azithromycin use (OR=13.4 [95% CI, 2.14 to 84]); and higher D-dimer levels (OR=2.8 [95% CI, 1.1 to 7.3]). In conclusion, patients diagnosed with AA had 3.1 times significant increase in mortality rate versus patients without diagnosis of AA in COVID-19 patients. Older age, male gender, azithromycin use and higher baseline D-dimer levels were predictors of mortality.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalAmerican Journal of Cardiology
Volume147
DOIs
StatePublished - May 15 2021
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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