Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations

Manish Parikh, Jessica Hetherington, Sheetal Sheth, Jamie Seiler, Harry Ostrer, Glenn Gerhard, Craig Wood, Christopher Still

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Genetic factors likely play a role in obesity and the outcomes after bariatric surgery. Single nucleotide polymorphisms in or near the insulin-induced gene 2 (INSIG-2), fat mass and obesity-associated gene (FTO), melanocortin 4 receptor gene (MC4R), and proprotein convertase subtilisn/kexin type 1 gene (PCSK-1) have been associated with class III obesity in whites. Minimal data are available regarding the genetic susceptibility to obesity in class III obese nonwhites, especially Hispanics. Our objective was to perform a comparative analysis of 4 common genetic variants (INSIG-2, FTO, MC4R, and PCSK-1) associated with obesity in a diverse population of bariatric surgery patients to determine whether a difference exists by ethnicity (white versus Hispanic). The setting of the study was 2 university hospitals in the United States. Methods: Bariatric surgery patients from 2 different institutions were enrolled prospectively, and genotyping was performed. Differences in the distribution of INSIG-2, FTO, MC4R, and PCSK-1 single nucleotide polymorphisms among the different ethnicities (whites and Hispanics) were compared using an additive model (0, 1, or 2 risk alleles). A propensity-matched analysis was used to account for cohort differences. Results: A total of 1276 bariatric patients were genotyped for the INSIG-2, FTO, MC4R, and PCSK-1 obesity single nucleotide polymorphisms. Statistically significant differences in FTO, INSIG-2, MC4R, and PCSK-1 were seen using an additive model. FTO, PCSK-1, and MC4R (test for trend) remained significantly different in the propensity analysis. Conclusion: Significant differences in the frequencies of several common obesity susceptibility variants in or near FTO, PCSK-1, and MC4R were found in white and Hispanic patients with class III obesity undergoing bariatric surgery. Larger studies in more class III obese Hispanics of different nationalities are needed.

Original languageEnglish (US)
Pages (from-to)436-441
Number of pages6
JournalSurgery for Obesity and Related Diseases
Volume9
Issue number3
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Bariatrics
Obesity
Alleles
Receptor, Melanocortin, Type 4
Proprotein Convertases
Population
Genes
Hispanic Americans
Bariatric Surgery
Insulin
Single Nucleotide Polymorphism

Keywords

  • Alleles
  • Bariatric surgery
  • Frequency
  • Genes
  • Genetics
  • Genotyping
  • Hispanics
  • Obesity

ASJC Scopus subject areas

  • Surgery

Cite this

Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations. / Parikh, Manish; Hetherington, Jessica; Sheth, Sheetal; Seiler, Jamie; Ostrer, Harry; Gerhard, Glenn; Wood, Craig; Still, Christopher.

In: Surgery for Obesity and Related Diseases, Vol. 9, No. 3, 05.2013, p. 436-441.

Research output: Contribution to journalArticle

Parikh, Manish ; Hetherington, Jessica ; Sheth, Sheetal ; Seiler, Jamie ; Ostrer, Harry ; Gerhard, Glenn ; Wood, Craig ; Still, Christopher. / Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations. In: Surgery for Obesity and Related Diseases. 2013 ; Vol. 9, No. 3. pp. 436-441.
@article{ee3a106a2a5e4ff5bb380aee90b8e472,
title = "Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations",
abstract = "Background: Genetic factors likely play a role in obesity and the outcomes after bariatric surgery. Single nucleotide polymorphisms in or near the insulin-induced gene 2 (INSIG-2), fat mass and obesity-associated gene (FTO), melanocortin 4 receptor gene (MC4R), and proprotein convertase subtilisn/kexin type 1 gene (PCSK-1) have been associated with class III obesity in whites. Minimal data are available regarding the genetic susceptibility to obesity in class III obese nonwhites, especially Hispanics. Our objective was to perform a comparative analysis of 4 common genetic variants (INSIG-2, FTO, MC4R, and PCSK-1) associated with obesity in a diverse population of bariatric surgery patients to determine whether a difference exists by ethnicity (white versus Hispanic). The setting of the study was 2 university hospitals in the United States. Methods: Bariatric surgery patients from 2 different institutions were enrolled prospectively, and genotyping was performed. Differences in the distribution of INSIG-2, FTO, MC4R, and PCSK-1 single nucleotide polymorphisms among the different ethnicities (whites and Hispanics) were compared using an additive model (0, 1, or 2 risk alleles). A propensity-matched analysis was used to account for cohort differences. Results: A total of 1276 bariatric patients were genotyped for the INSIG-2, FTO, MC4R, and PCSK-1 obesity single nucleotide polymorphisms. Statistically significant differences in FTO, INSIG-2, MC4R, and PCSK-1 were seen using an additive model. FTO, PCSK-1, and MC4R (test for trend) remained significantly different in the propensity analysis. Conclusion: Significant differences in the frequencies of several common obesity susceptibility variants in or near FTO, PCSK-1, and MC4R were found in white and Hispanic patients with class III obesity undergoing bariatric surgery. Larger studies in more class III obese Hispanics of different nationalities are needed.",
keywords = "Alleles, Bariatric surgery, Frequency, Genes, Genetics, Genotyping, Hispanics, Obesity",
author = "Manish Parikh and Jessica Hetherington and Sheetal Sheth and Jamie Seiler and Harry Ostrer and Glenn Gerhard and Craig Wood and Christopher Still",
year = "2013",
month = "5",
doi = "10.1016/j.soard.2012.04.004",
language = "English (US)",
volume = "9",
pages = "436--441",
journal = "Surgery for Obesity and Related Diseases",
issn = "1550-7289",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations

AU - Parikh, Manish

AU - Hetherington, Jessica

AU - Sheth, Sheetal

AU - Seiler, Jamie

AU - Ostrer, Harry

AU - Gerhard, Glenn

AU - Wood, Craig

AU - Still, Christopher

PY - 2013/5

Y1 - 2013/5

N2 - Background: Genetic factors likely play a role in obesity and the outcomes after bariatric surgery. Single nucleotide polymorphisms in or near the insulin-induced gene 2 (INSIG-2), fat mass and obesity-associated gene (FTO), melanocortin 4 receptor gene (MC4R), and proprotein convertase subtilisn/kexin type 1 gene (PCSK-1) have been associated with class III obesity in whites. Minimal data are available regarding the genetic susceptibility to obesity in class III obese nonwhites, especially Hispanics. Our objective was to perform a comparative analysis of 4 common genetic variants (INSIG-2, FTO, MC4R, and PCSK-1) associated with obesity in a diverse population of bariatric surgery patients to determine whether a difference exists by ethnicity (white versus Hispanic). The setting of the study was 2 university hospitals in the United States. Methods: Bariatric surgery patients from 2 different institutions were enrolled prospectively, and genotyping was performed. Differences in the distribution of INSIG-2, FTO, MC4R, and PCSK-1 single nucleotide polymorphisms among the different ethnicities (whites and Hispanics) were compared using an additive model (0, 1, or 2 risk alleles). A propensity-matched analysis was used to account for cohort differences. Results: A total of 1276 bariatric patients were genotyped for the INSIG-2, FTO, MC4R, and PCSK-1 obesity single nucleotide polymorphisms. Statistically significant differences in FTO, INSIG-2, MC4R, and PCSK-1 were seen using an additive model. FTO, PCSK-1, and MC4R (test for trend) remained significantly different in the propensity analysis. Conclusion: Significant differences in the frequencies of several common obesity susceptibility variants in or near FTO, PCSK-1, and MC4R were found in white and Hispanic patients with class III obesity undergoing bariatric surgery. Larger studies in more class III obese Hispanics of different nationalities are needed.

AB - Background: Genetic factors likely play a role in obesity and the outcomes after bariatric surgery. Single nucleotide polymorphisms in or near the insulin-induced gene 2 (INSIG-2), fat mass and obesity-associated gene (FTO), melanocortin 4 receptor gene (MC4R), and proprotein convertase subtilisn/kexin type 1 gene (PCSK-1) have been associated with class III obesity in whites. Minimal data are available regarding the genetic susceptibility to obesity in class III obese nonwhites, especially Hispanics. Our objective was to perform a comparative analysis of 4 common genetic variants (INSIG-2, FTO, MC4R, and PCSK-1) associated with obesity in a diverse population of bariatric surgery patients to determine whether a difference exists by ethnicity (white versus Hispanic). The setting of the study was 2 university hospitals in the United States. Methods: Bariatric surgery patients from 2 different institutions were enrolled prospectively, and genotyping was performed. Differences in the distribution of INSIG-2, FTO, MC4R, and PCSK-1 single nucleotide polymorphisms among the different ethnicities (whites and Hispanics) were compared using an additive model (0, 1, or 2 risk alleles). A propensity-matched analysis was used to account for cohort differences. Results: A total of 1276 bariatric patients were genotyped for the INSIG-2, FTO, MC4R, and PCSK-1 obesity single nucleotide polymorphisms. Statistically significant differences in FTO, INSIG-2, MC4R, and PCSK-1 were seen using an additive model. FTO, PCSK-1, and MC4R (test for trend) remained significantly different in the propensity analysis. Conclusion: Significant differences in the frequencies of several common obesity susceptibility variants in or near FTO, PCSK-1, and MC4R were found in white and Hispanic patients with class III obesity undergoing bariatric surgery. Larger studies in more class III obese Hispanics of different nationalities are needed.

KW - Alleles

KW - Bariatric surgery

KW - Frequency

KW - Genes

KW - Genetics

KW - Genotyping

KW - Hispanics

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84878599129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878599129&partnerID=8YFLogxK

U2 - 10.1016/j.soard.2012.04.004

DO - 10.1016/j.soard.2012.04.004

M3 - Article

VL - 9

SP - 436

EP - 441

JO - Surgery for Obesity and Related Diseases

JF - Surgery for Obesity and Related Diseases

SN - 1550-7289

IS - 3

ER -