Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease

An International VT Ablation Center Collaborative Group study

Roderick Tung, Marmar Vaseghi, David S. Frankel, Pasquale Vergara, Luigi Di Biase, Koichi Nagashima, Ricky Yu, Sitaram Vangala, Chi Hong Tseng, Eue Keun Choi, Shaan Khurshid, Mehul Patel, Nilesh Mathuria, Shiro Nakahara, Wendy S. Tzou, William H. Sauer, Kairav Vakil, Usha Tedrow, J. David Burkhardt, Venkatakrishna N. Tholakanahalli & 13 others Anastasios Saliaris, Timm Dickfeld, J. Peter Weiss, T. Jared Bunch, Madhu Reddy, Arun Kanmanthareddy, David J. Callans, Dhanunjaya Lakkireddy, Andrea Natale, Francis Marchlinski, William G. Stevenson, Paolo Della Bella, Kalyanam Shivkumar

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Background The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. Objective The purpose of this study was to examine the association between VT recurrence after ablation and survival in patients with scar-related VT. Methods Analysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality. Results One-year freedom from VT recurrence was 70% (72% in ischemic and 68% in nonischemic cardiomyopathy). Fifty-seven patients (3%) underwent cardiac transplantation, and 216 (10%) died during follow-up. At 1 year, the estimated rate of transplant and/or mortality was 15% (same for ischemic and nonischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence than in those with recurrence (90% vs 71%, P

Original languageEnglish (US)
Pages (from-to)1997-2007
Number of pages11
JournalHeart Rhythm
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

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Catheter Ablation
Ventricular Tachycardia
Heart Diseases
Survival
Recurrence
Mortality
Transplants
Cardiomyopathies
Cicatrix
Kaplan-Meier Estimate
Heart Transplantation
Proportional Hazards Models

Keywords

  • Ablation
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease : An International VT Ablation Center Collaborative Group study. / Tung, Roderick; Vaseghi, Marmar; Frankel, David S.; Vergara, Pasquale; Di Biase, Luigi; Nagashima, Koichi; Yu, Ricky; Vangala, Sitaram; Tseng, Chi Hong; Choi, Eue Keun; Khurshid, Shaan; Patel, Mehul; Mathuria, Nilesh; Nakahara, Shiro; Tzou, Wendy S.; Sauer, William H.; Vakil, Kairav; Tedrow, Usha; Burkhardt, J. David; Tholakanahalli, Venkatakrishna N.; Saliaris, Anastasios; Dickfeld, Timm; Weiss, J. Peter; Bunch, T. Jared; Reddy, Madhu; Kanmanthareddy, Arun; Callans, David J.; Lakkireddy, Dhanunjaya; Natale, Andrea; Marchlinski, Francis; Stevenson, William G.; Della Bella, Paolo; Shivkumar, Kalyanam.

In: Heart Rhythm, Vol. 12, No. 9, 01.09.2015, p. 1997-2007.

Research output: Contribution to journalArticle

Tung, R, Vaseghi, M, Frankel, DS, Vergara, P, Di Biase, L, Nagashima, K, Yu, R, Vangala, S, Tseng, CH, Choi, EK, Khurshid, S, Patel, M, Mathuria, N, Nakahara, S, Tzou, WS, Sauer, WH, Vakil, K, Tedrow, U, Burkhardt, JD, Tholakanahalli, VN, Saliaris, A, Dickfeld, T, Weiss, JP, Bunch, TJ, Reddy, M, Kanmanthareddy, A, Callans, DJ, Lakkireddy, D, Natale, A, Marchlinski, F, Stevenson, WG, Della Bella, P & Shivkumar, K 2015, 'Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study', Heart Rhythm, vol. 12, no. 9, pp. 1997-2007. https://doi.org/10.1016/j.hrthm.2015.05.036
Tung, Roderick ; Vaseghi, Marmar ; Frankel, David S. ; Vergara, Pasquale ; Di Biase, Luigi ; Nagashima, Koichi ; Yu, Ricky ; Vangala, Sitaram ; Tseng, Chi Hong ; Choi, Eue Keun ; Khurshid, Shaan ; Patel, Mehul ; Mathuria, Nilesh ; Nakahara, Shiro ; Tzou, Wendy S. ; Sauer, William H. ; Vakil, Kairav ; Tedrow, Usha ; Burkhardt, J. David ; Tholakanahalli, Venkatakrishna N. ; Saliaris, Anastasios ; Dickfeld, Timm ; Weiss, J. Peter ; Bunch, T. Jared ; Reddy, Madhu ; Kanmanthareddy, Arun ; Callans, David J. ; Lakkireddy, Dhanunjaya ; Natale, Andrea ; Marchlinski, Francis ; Stevenson, William G. ; Della Bella, Paolo ; Shivkumar, Kalyanam. / Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease : An International VT Ablation Center Collaborative Group study. In: Heart Rhythm. 2015 ; Vol. 12, No. 9. pp. 1997-2007.
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abstract = "Background The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. Objective The purpose of this study was to examine the association between VT recurrence after ablation and survival in patients with scar-related VT. Methods Analysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality. Results One-year freedom from VT recurrence was 70{\%} (72{\%} in ischemic and 68{\%} in nonischemic cardiomyopathy). Fifty-seven patients (3{\%}) underwent cardiac transplantation, and 216 (10{\%}) died during follow-up. At 1 year, the estimated rate of transplant and/or mortality was 15{\%} (same for ischemic and nonischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence than in those with recurrence (90{\%} vs 71{\%}, P",
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T1 - Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease

T2 - An International VT Ablation Center Collaborative Group study

AU - Tung, Roderick

AU - Vaseghi, Marmar

AU - Frankel, David S.

AU - Vergara, Pasquale

AU - Di Biase, Luigi

AU - Nagashima, Koichi

AU - Yu, Ricky

AU - Vangala, Sitaram

AU - Tseng, Chi Hong

AU - Choi, Eue Keun

AU - Khurshid, Shaan

AU - Patel, Mehul

AU - Mathuria, Nilesh

AU - Nakahara, Shiro

AU - Tzou, Wendy S.

AU - Sauer, William H.

AU - Vakil, Kairav

AU - Tedrow, Usha

AU - Burkhardt, J. David

AU - Tholakanahalli, Venkatakrishna N.

AU - Saliaris, Anastasios

AU - Dickfeld, Timm

AU - Weiss, J. Peter

AU - Bunch, T. Jared

AU - Reddy, Madhu

AU - Kanmanthareddy, Arun

AU - Callans, David J.

AU - Lakkireddy, Dhanunjaya

AU - Natale, Andrea

AU - Marchlinski, Francis

AU - Stevenson, William G.

AU - Della Bella, Paolo

AU - Shivkumar, Kalyanam

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Background The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. Objective The purpose of this study was to examine the association between VT recurrence after ablation and survival in patients with scar-related VT. Methods Analysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality. Results One-year freedom from VT recurrence was 70% (72% in ischemic and 68% in nonischemic cardiomyopathy). Fifty-seven patients (3%) underwent cardiac transplantation, and 216 (10%) died during follow-up. At 1 year, the estimated rate of transplant and/or mortality was 15% (same for ischemic and nonischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence than in those with recurrence (90% vs 71%, P

AB - Background The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. Objective The purpose of this study was to examine the association between VT recurrence after ablation and survival in patients with scar-related VT. Methods Analysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality. Results One-year freedom from VT recurrence was 70% (72% in ischemic and 68% in nonischemic cardiomyopathy). Fifty-seven patients (3%) underwent cardiac transplantation, and 216 (10%) died during follow-up. At 1 year, the estimated rate of transplant and/or mortality was 15% (same for ischemic and nonischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence than in those with recurrence (90% vs 71%, P

KW - Ablation

KW - Ventricular tachycardia

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U2 - 10.1016/j.hrthm.2015.05.036

DO - 10.1016/j.hrthm.2015.05.036

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JO - Heart Rhythm

JF - Heart Rhythm

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