Free radicals in cerebral ischemia

Eugene S. Flamm, H. B. Demopoulos, M. L. Seligman, R. G. Poser, J. Ransohoff

Research output: Contribution to journalArticle

486 Citations (Scopus)

Abstract

The possibility that cerebral ischemia may initiate a series of pathological free radical reactions within the membrane components of the CNS was investigated in the cat. The normally occurring electron transport radicals require adequate molecular oxygen for orderly transport of electrons and protons. A decrease in tissue oxygen removes the controls over the electron transport radicals, and allows them to initiate pathologic radical reactions among cell membranes such as mitochondria. Pathologic radical reactions result in multiple products, each of which may be present in too small a concentration to permit their detection at early time periods. It is possible to follow the time course, however, by the decrease of a major antioxidant as it is consumed by the pathologic radical reactions. For this reason, ascorbic acid was measured in ischemic and control brain following middle cerebral artery occlusion. There was a progressive decrease in the amount of detectable ascorbic acid ranging from 25% at 1 hour to 65% at 24 hours after occlusion. The reduction of this normally occurring antioxidant and free radical scavenger may indicate consumption of ascorbic acid in an attempt to quench pathologic free radical reactions occurring within the components of cytomembranes.

Original languageEnglish (US)
Pages (from-to)445-447
Number of pages3
JournalStroke
Volume9
Issue number5
StatePublished - 1978
Externally publishedYes

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Electron Transport
Brain Ischemia
Ascorbic Acid
Free Radicals
Antioxidants
Oxygen
Free Radical Scavengers
Middle Cerebral Artery Infarction
Protons
Mitochondria
Cats
Cell Membrane
Membranes
Brain

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Flamm, E. S., Demopoulos, H. B., Seligman, M. L., Poser, R. G., & Ransohoff, J. (1978). Free radicals in cerebral ischemia. Stroke, 9(5), 445-447.

Free radicals in cerebral ischemia. / Flamm, Eugene S.; Demopoulos, H. B.; Seligman, M. L.; Poser, R. G.; Ransohoff, J.

In: Stroke, Vol. 9, No. 5, 1978, p. 445-447.

Research output: Contribution to journalArticle

Flamm, ES, Demopoulos, HB, Seligman, ML, Poser, RG & Ransohoff, J 1978, 'Free radicals in cerebral ischemia', Stroke, vol. 9, no. 5, pp. 445-447.
Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J. Free radicals in cerebral ischemia. Stroke. 1978;9(5):445-447.
Flamm, Eugene S. ; Demopoulos, H. B. ; Seligman, M. L. ; Poser, R. G. ; Ransohoff, J. / Free radicals in cerebral ischemia. In: Stroke. 1978 ; Vol. 9, No. 5. pp. 445-447.
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