Fractionated radiotherapy for intracranial meningiomas

Vinai Gondi, Wolfgang A. Tome, Minesh P. Mehta

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Fractionated external beam radiotherapy (EBRT) has multiple roles in the management of intracranial meningiomas. In multiple series post-operative EBRT has shown improved progression-free survival following subtotal resection and a reduction in long-term failures following an apparent gross total resection. In the definitive setting, the use of EBRT has increased as the growing utilization of neuro-imaging for various conditions identifies skull-based lesions which are not easily resectable. Optic nerve sheath meningiomas represent a classic example of the use of definitive EBRT, given the frequent visual sequelae of surgery or observation. EBRT planning is highly individualized and requires a detailed understanding of tumor grade, adjacent radiosensitive structures such as the anterior optic apparatus, and radiographic characteristics of the tumor such as hyperostosis.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalJournal of Neuro-Oncology
Volume99
Issue number3
DOIs
Publication statusPublished - Sep 1 2010
Externally publishedYes

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Keywords

  • EBRT
  • Fractionated stereotactic radiotherapy
  • IMRT
  • Meningiomas
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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