Forgetting as an active process

An fMRI investigation of item-method-directed forgetting

Glenn R. Wylie, John J. Foxe, Tracy L. Taylor

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Using event-related functional magnetic resonance imaging (fMRI), we examined the blood oxygen level-dependent response associated with intentional remembering and forgetting. In an item-method directed forgetting paradigm, participants were presented with words, one at a time, each of which was followed after a brief delay by an instruction to Remember or Forget. Behavioral data revealed a directed forgetting effect: greater recognition of to-be-remembered than to-be-forgotten words. We used this behavioral recognition data to sort the fMRI data into 4 conditions based on the combination of memory instruction and behavioral outcome. When contrasted with unintentional forgetting, intentional forgetting was associated with increased activity in hippocampus (Broadmann area [BA] 35) and superior frontal gyrus (BA10/11); when contrasted with intentional remembering, intentional forgetting was associated with activity in medial frontal gyrus (BA10), middle temporal gyrus (BA21), parahippocampal gyrus (BA34 and 35), and cingulate gyrus (BA31). Thus, intentional forgetting depends on neural structures distinct from those involved in unintentional forgetting and intentional remembering. These results challenge the standard selective rehearsal account of item-method directed forgetting and suggest that frontal control processes may be critical for directed forgetting.

Original languageEnglish (US)
Pages (from-to)670-682
Number of pages13
JournalCerebral Cortex
Volume18
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Prefrontal Cortex
Magnetic Resonance Imaging
Parahippocampal Gyrus
Gyrus Cinguli
Temporal Lobe
Hippocampus
Oxygen
Recognition (Psychology)

Keywords

  • Attention
  • Control
  • Directed forgetting
  • fMRI
  • Memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Forgetting as an active process : An fMRI investigation of item-method-directed forgetting. / Wylie, Glenn R.; Foxe, John J.; Taylor, Tracy L.

In: Cerebral Cortex, Vol. 18, No. 3, 03.2008, p. 670-682.

Research output: Contribution to journalArticle

Wylie, Glenn R. ; Foxe, John J. ; Taylor, Tracy L. / Forgetting as an active process : An fMRI investigation of item-method-directed forgetting. In: Cerebral Cortex. 2008 ; Vol. 18, No. 3. pp. 670-682.
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