TY - JOUR
T1 - Follow-up evaluation of cervicovaginal human papillomavirus infection in adolescents
AU - Rosenfeld, Walter D.
AU - Rose, Elizabeth
AU - Vermund, Sten H.
AU - Schreiber, Klaus
AU - Burk, Robert D.
N1 - Funding Information:
Condylomata acuminata, or anogenital warts, are caused by HPV infection and represent the most commonly diag- Submitted for publication Dec. 6, 1991; accepted March 11, 1992. Reprint requests: Robert D. Burk, MD, Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10561. *Now at Morristown Memorial Hospital, Morristown, N.J. **Now at the College of Physicians and Surgeons, Columbia University, New York, N.Y. ***Now at the Epidemiology Branch, Division of AIDS, National InstitUte of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. ****Recipient of a faculty award from the American Cancer Society. 9/27/37826 nosed viral sexually transmitted disease in the United States.2, 3 Numerous epidemiologic studies have shown that cancer of the cervix and its precursor lesions share many characteristics of an STD, but only recently has HPV been implicated as the etiologic agent. 4-6 In addition, histologic analysis of cervical squamous intraepithelial lesions has shown that these lesions share morphologic features with
PY - 1992/8
Y1 - 1992/8
N2 - We performed a second examination for human papillomavirus (HPV) DNA on 51 sexually experienced 13- to 21-year-old (mean=17.8 years) female patients seen at an urban teaching hospital. Cervicovaginal lavages were performed 6 to 36 months apart (median=13.3 months) to collect cells for HPV DNA detection and typing by Southern blot hybridization. At the first and second visits, 39.2% (20/51) and 25.5% (13/51) of patients, respectively, were infected with HPV. Collectively, 56.9% (29/51) of patients had at least one positive HPV test result. Although 7.8% (4/51) were infected with HPV at both visits, only one patient had infection with the same HPV type. These findings suggest that although HPV infection is a common sexually transmitted disease, genotype-specific HPV infection detected by Southern blot at two visits was rare.
AB - We performed a second examination for human papillomavirus (HPV) DNA on 51 sexually experienced 13- to 21-year-old (mean=17.8 years) female patients seen at an urban teaching hospital. Cervicovaginal lavages were performed 6 to 36 months apart (median=13.3 months) to collect cells for HPV DNA detection and typing by Southern blot hybridization. At the first and second visits, 39.2% (20/51) and 25.5% (13/51) of patients, respectively, were infected with HPV. Collectively, 56.9% (29/51) of patients had at least one positive HPV test result. Although 7.8% (4/51) were infected with HPV at both visits, only one patient had infection with the same HPV type. These findings suggest that although HPV infection is a common sexually transmitted disease, genotype-specific HPV infection detected by Southern blot at two visits was rare.
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U2 - 10.1016/S0022-3476(05)81212-0
DO - 10.1016/S0022-3476(05)81212-0
M3 - Article
C2 - 1322456
AN - SCOPUS:0026668228
SN - 0022-3476
VL - 121
SP - 307
EP - 311
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 2
ER -
