Folate intake and risk of pancreatic cancer

Pooled analysis of prospective cohort studies

Ying Bao, Dominique S. Michaud, Donna Spiegelman, Demetrius Albanes, Kristin E. Anderson, Leslie Bernstein, Piet A. Van Den Brandt, Dallas R. English, Jo L. Freudenheim, Charles S. Fuchs, Graham G. Giles, Edward Giovannucci, R. Alexandra Goldbohm, Niclas Håkansson, Pamela L. Horn-Ross, Eric J. Jacobs, Cari M. Kitahara, James R. Marshall, Anthony B. Miller, Kim Robien & 8 others Thomas E. Rohan, Arthur Schatzkin, Victoria L. Stevens, Rachael Z. Stolzenberg-Solomon, Jarmo Virtamo, Alicja Wolk, Regina G. Ziegler, Stephanie A. Smith-Warner

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95% CI = 0.90 to 1.25, Ptrend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95% CI = 0.80 to 1.16, Ptrend = .90). No between-study heterogeneity was observed (for dietary folate, Pheterogeneity = .15; for total folate, Pheterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.

Original languageEnglish (US)
Pages (from-to)1840-1850
Number of pages11
JournalJournal of the National Cancer Institute
Volume103
Issue number24
DOIs
StatePublished - Dec 21 2010

Fingerprint

Pancreatic Neoplasms
Folic Acid
Cohort Studies
Prospective Studies
Confidence Intervals
Proportional Hazards Models
Sample Size
Epidemiologic Studies
Food

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bao, Y., Michaud, D. S., Spiegelman, D., Albanes, D., Anderson, K. E., Bernstein, L., ... Smith-Warner, S. A. (2010). Folate intake and risk of pancreatic cancer: Pooled analysis of prospective cohort studies. Journal of the National Cancer Institute, 103(24), 1840-1850. https://doi.org/10.1093/jnci/djr431

Folate intake and risk of pancreatic cancer : Pooled analysis of prospective cohort studies. / Bao, Ying; Michaud, Dominique S.; Spiegelman, Donna; Albanes, Demetrius; Anderson, Kristin E.; Bernstein, Leslie; Van Den Brandt, Piet A.; English, Dallas R.; Freudenheim, Jo L.; Fuchs, Charles S.; Giles, Graham G.; Giovannucci, Edward; Goldbohm, R. Alexandra; Håkansson, Niclas; Horn-Ross, Pamela L.; Jacobs, Eric J.; Kitahara, Cari M.; Marshall, James R.; Miller, Anthony B.; Robien, Kim; Rohan, Thomas E.; Schatzkin, Arthur; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael Z.; Virtamo, Jarmo; Wolk, Alicja; Ziegler, Regina G.; Smith-Warner, Stephanie A.

In: Journal of the National Cancer Institute, Vol. 103, No. 24, 21.12.2010, p. 1840-1850.

Research output: Contribution to journalArticle

Bao, Y, Michaud, DS, Spiegelman, D, Albanes, D, Anderson, KE, Bernstein, L, Van Den Brandt, PA, English, DR, Freudenheim, JL, Fuchs, CS, Giles, GG, Giovannucci, E, Goldbohm, RA, Håkansson, N, Horn-Ross, PL, Jacobs, EJ, Kitahara, CM, Marshall, JR, Miller, AB, Robien, K, Rohan, TE, Schatzkin, A, Stevens, VL, Stolzenberg-Solomon, RZ, Virtamo, J, Wolk, A, Ziegler, RG & Smith-Warner, SA 2010, 'Folate intake and risk of pancreatic cancer: Pooled analysis of prospective cohort studies', Journal of the National Cancer Institute, vol. 103, no. 24, pp. 1840-1850. https://doi.org/10.1093/jnci/djr431
Bao Y, Michaud DS, Spiegelman D, Albanes D, Anderson KE, Bernstein L et al. Folate intake and risk of pancreatic cancer: Pooled analysis of prospective cohort studies. Journal of the National Cancer Institute. 2010 Dec 21;103(24):1840-1850. https://doi.org/10.1093/jnci/djr431
Bao, Ying ; Michaud, Dominique S. ; Spiegelman, Donna ; Albanes, Demetrius ; Anderson, Kristin E. ; Bernstein, Leslie ; Van Den Brandt, Piet A. ; English, Dallas R. ; Freudenheim, Jo L. ; Fuchs, Charles S. ; Giles, Graham G. ; Giovannucci, Edward ; Goldbohm, R. Alexandra ; Håkansson, Niclas ; Horn-Ross, Pamela L. ; Jacobs, Eric J. ; Kitahara, Cari M. ; Marshall, James R. ; Miller, Anthony B. ; Robien, Kim ; Rohan, Thomas E. ; Schatzkin, Arthur ; Stevens, Victoria L. ; Stolzenberg-Solomon, Rachael Z. ; Virtamo, Jarmo ; Wolk, Alicja ; Ziegler, Regina G. ; Smith-Warner, Stephanie A. / Folate intake and risk of pancreatic cancer : Pooled analysis of prospective cohort studies. In: Journal of the National Cancer Institute. 2010 ; Vol. 103, No. 24. pp. 1840-1850.
@article{68af967575bd4aafb3f9a5502f400976,
title = "Folate intake and risk of pancreatic cancer: Pooled analysis of prospective cohort studies",
abstract = "Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95{\%} confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95{\%} CI = 0.90 to 1.25, Ptrend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95{\%} CI = 0.80 to 1.16, Ptrend = .90). No between-study heterogeneity was observed (for dietary folate, Pheterogeneity = .15; for total folate, Pheterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.",
author = "Ying Bao and Michaud, {Dominique S.} and Donna Spiegelman and Demetrius Albanes and Anderson, {Kristin E.} and Leslie Bernstein and {Van Den Brandt}, {Piet A.} and English, {Dallas R.} and Freudenheim, {Jo L.} and Fuchs, {Charles S.} and Giles, {Graham G.} and Edward Giovannucci and Goldbohm, {R. Alexandra} and Niclas H{\aa}kansson and Horn-Ross, {Pamela L.} and Jacobs, {Eric J.} and Kitahara, {Cari M.} and Marshall, {James R.} and Miller, {Anthony B.} and Kim Robien and Rohan, {Thomas E.} and Arthur Schatzkin and Stevens, {Victoria L.} and Stolzenberg-Solomon, {Rachael Z.} and Jarmo Virtamo and Alicja Wolk and Ziegler, {Regina G.} and Smith-Warner, {Stephanie A.}",
year = "2010",
month = "12",
day = "21",
doi = "10.1093/jnci/djr431",
language = "English (US)",
volume = "103",
pages = "1840--1850",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "24",

}

TY - JOUR

T1 - Folate intake and risk of pancreatic cancer

T2 - Pooled analysis of prospective cohort studies

AU - Bao, Ying

AU - Michaud, Dominique S.

AU - Spiegelman, Donna

AU - Albanes, Demetrius

AU - Anderson, Kristin E.

AU - Bernstein, Leslie

AU - Van Den Brandt, Piet A.

AU - English, Dallas R.

AU - Freudenheim, Jo L.

AU - Fuchs, Charles S.

AU - Giles, Graham G.

AU - Giovannucci, Edward

AU - Goldbohm, R. Alexandra

AU - Håkansson, Niclas

AU - Horn-Ross, Pamela L.

AU - Jacobs, Eric J.

AU - Kitahara, Cari M.

AU - Marshall, James R.

AU - Miller, Anthony B.

AU - Robien, Kim

AU - Rohan, Thomas E.

AU - Schatzkin, Arthur

AU - Stevens, Victoria L.

AU - Stolzenberg-Solomon, Rachael Z.

AU - Virtamo, Jarmo

AU - Wolk, Alicja

AU - Ziegler, Regina G.

AU - Smith-Warner, Stephanie A.

PY - 2010/12/21

Y1 - 2010/12/21

N2 - Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95% CI = 0.90 to 1.25, Ptrend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95% CI = 0.80 to 1.16, Ptrend = .90). No between-study heterogeneity was observed (for dietary folate, Pheterogeneity = .15; for total folate, Pheterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.

AB - Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95% CI = 0.90 to 1.25, Ptrend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95% CI = 0.80 to 1.16, Ptrend = .90). No between-study heterogeneity was observed (for dietary folate, Pheterogeneity = .15; for total folate, Pheterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.

UR - http://www.scopus.com/inward/record.url?scp=84856595269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856595269&partnerID=8YFLogxK

U2 - 10.1093/jnci/djr431

DO - 10.1093/jnci/djr431

M3 - Article

VL - 103

SP - 1840

EP - 1850

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 24

ER -