Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart

Bin Zhou, Qing Ma, Won Kong Sek, Yongwu Hu, Patrick H. Campbell, Francis X. McGowan, Kate G. Ackerman, Bingruo Wu, Bin Zhou, Sergei G. Tevosian, William T. Pu

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Aberrant transcriptional regulation contributes to the pathogenesis of both congenital and adult forms of heart disease. While the transcriptional regulator friend of Gata 2 (FOG2) is known to be essential for heart morphogenesis and coronary development, its tissue-specific function has not been previously investigated. Additionally, little is known about the role of FOG2 in the adult heart. Here we used spatiotemporally regulated inactivation of Fog2 to delineate its function in both the embryonic and adult mouse heart. Early cardiomyocyte-restricted loss of Fog2 recapitulated the cardiac and coronary defects of the Fog2 germline murine knockouts. Later cardiomyocyte-restricted loss of Fog2 (Fog2MC) did not result in defects in cardiac structure or coronary vessel formation. However, Fog2 MC adult mice had severely depressed ventricular function and died at 8-14 weeks. Fog2MC adult hearts displayed a paucity of coronary vessels, associated with myocardial hypoxia, increased cardiomyocyte apoptosis, and cardiac fibrosis. Induced inactivation of Fog2 in the adult mouse heart resulted in similar phenotypes, as did ablation of the FOG2 interaction with the transcription factor GATA4. Loss of the FOG2 or FOG2-GATA4 interaction altered the expression of a panel of angiogenesis-related genes. Collectively, our data indicate that FOG2 regulates adult heart function and coronary angiogenesis.

Original languageEnglish (US)
Pages (from-to)1462-1476
Number of pages15
JournalJournal of Clinical Investigation
Volume119
Issue number6
DOIs
StatePublished - Jun 1 2009

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart'. Together they form a unique fingerprint.

  • Cite this

    Zhou, B., Ma, Q., Sek, W. K., Hu, Y., Campbell, P. H., McGowan, F. X., Ackerman, K. G., Wu, B., Zhou, B., Tevosian, S. G., & Pu, W. T. (2009). Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. Journal of Clinical Investigation, 119(6), 1462-1476. https://doi.org/10.1172/JCI38723