FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro

Barry M. Kacinski, Kimberly A. Scata, Darryl Carter, Lisa D. Yee, Eva Sapi, Bonnie L. King, Setsuko K. Chambers, Michael A. Jones, Mary H. Pirro, E. Richard Stanley, Larry R. Rohrschneider

Research output: Contribution to journalArticle

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Abstract

The expression in vivo of FMS transcripts and antigen by neoplastic epithelial cells was demonstrated immunohistochemically or by in situ hybridization in sixteen of seventeen human breast carcinoma specimens and one case of sclerosing adenosis. Expression of CSF-1 receptor (FMS) transcripts and protein was also observed in vitro in two or three breast carcinoma-derived cell lines and was dramatically increased by dexamethasone, a potent glucocorticoid and inducer of mammary epithelial cell differentiation. Immunohistochemical staining with an anti-CSF-1 antibody identified neoplastic epithelial cell co-expression of fms and CSF-1 antigens in more than one-third of the fms-positive invasive carcinoma specimens. These results suggest that autocrine and paracrine interactions of the lymphohematopoietic cytokine CSF-1 and its receptor may participate in the biology of human mammary neoplasms.

Original languageEnglish (US)
Pages (from-to)941-952
Number of pages12
JournalOncogene
Volume6
Issue number6
StatePublished - Jun 1991

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Macrophage Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Epithelial Cells
Breast Neoplasms
Antigens
Proteins
Dexamethasone
Glucocorticoids
In Situ Hybridization
Cell Differentiation
Breast
Staining and Labeling
Cytokines
Carcinoma
Cell Line
Antibodies
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Kacinski, B. M., Scata, K. A., Carter, D., Yee, L. D., Sapi, E., King, B. L., ... Rohrschneider, L. R. (1991). FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro. Oncogene, 6(6), 941-952.

FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro. / Kacinski, Barry M.; Scata, Kimberly A.; Carter, Darryl; Yee, Lisa D.; Sapi, Eva; King, Bonnie L.; Chambers, Setsuko K.; Jones, Michael A.; Pirro, Mary H.; Stanley, E. Richard; Rohrschneider, Larry R.

In: Oncogene, Vol. 6, No. 6, 06.1991, p. 941-952.

Research output: Contribution to journalArticle

Kacinski, BM, Scata, KA, Carter, D, Yee, LD, Sapi, E, King, BL, Chambers, SK, Jones, MA, Pirro, MH, Stanley, ER & Rohrschneider, LR 1991, 'FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro', Oncogene, vol. 6, no. 6, pp. 941-952.
Kacinski BM, Scata KA, Carter D, Yee LD, Sapi E, King BL et al. FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro. Oncogene. 1991 Jun;6(6):941-952.
Kacinski, Barry M. ; Scata, Kimberly A. ; Carter, Darryl ; Yee, Lisa D. ; Sapi, Eva ; King, Bonnie L. ; Chambers, Setsuko K. ; Jones, Michael A. ; Pirro, Mary H. ; Stanley, E. Richard ; Rohrschneider, Larry R. / FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro. In: Oncogene. 1991 ; Vol. 6, No. 6. pp. 941-952.
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AU - King, Bonnie L.

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AB - The expression in vivo of FMS transcripts and antigen by neoplastic epithelial cells was demonstrated immunohistochemically or by in situ hybridization in sixteen of seventeen human breast carcinoma specimens and one case of sclerosing adenosis. Expression of CSF-1 receptor (FMS) transcripts and protein was also observed in vitro in two or three breast carcinoma-derived cell lines and was dramatically increased by dexamethasone, a potent glucocorticoid and inducer of mammary epithelial cell differentiation. Immunohistochemical staining with an anti-CSF-1 antibody identified neoplastic epithelial cell co-expression of fms and CSF-1 antigens in more than one-third of the fms-positive invasive carcinoma specimens. These results suggest that autocrine and paracrine interactions of the lymphohematopoietic cytokine CSF-1 and its receptor may participate in the biology of human mammary neoplasms.

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