FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro

B. M. Kacinski, K. A. Scata, D. Carter, L. D. Yee, E. Sapi, B. L. King, S. K.M.A. Chambers Jones, M. H. Pirro, E. R. Stanley, L. R. Rohrscneider

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123 Scopus citations

Abstract

The expression in vivo of FMS transcripts and antigen by neoplastic epithelial cells was demonstrated immunohistochemically or by in situ hybridization in sixteen of seventeen human breast carcinoma specimens and one case of sclerosing adenosis. Expression of CSF-1 receptor (FMS) transcripts and protein was also observed in vitro in two or three breast carcinoma-derived cell lines and was dramatically increased by dexamethasone, a potent glucocorticoid and inducer of mammary epithelial cell differentiation. Immunohistochemical staining with an anti-CSF-1 antibody identified neoplastic epithelial cell co-expression of fms and CSF-1 antigens in more than one-third of the fms-positive invasive carcinoma specimens. These results suggest that autocrine and paracrine interactions of the lymphohematopoietic cytokine CSF-1 and its receptor may participate in the biology of human mammary neoplasms.

Original languageEnglish (US)
Pages (from-to)941-952
Number of pages12
JournalOncogene
Volume6
Issue number6
StatePublished - Aug 23 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Kacinski, B. M., Scata, K. A., Carter, D., Yee, L. D., Sapi, E., King, B. L., Chambers Jones, S. K. M. A., Pirro, M. H., Stanley, E. R., & Rohrscneider, L. R. (1991). FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro. Oncogene, 6(6), 941-952.