TY - JOUR
T1 - Fluoxetine treatment of obsessive-compulsive disorder
T2 - An open clinical trial
AU - Liebowitz, Michael R.
AU - Eric, Hollander
AU - Frank, Schneier
AU - Raphael, Campeas
AU - Julie, Hatterer
AU - Laszlo, Papp
AU - Janet, Fairbanks
AU - Diana, Sandberg
AU - Sharon, Davies
AU - Maria, Stein
PY - 1989/12
Y1 - 1989/12
N2 - The selective serotonin reuptake blocker fluoxetine was administered to 49 patients with obsessivecompulsive disorder in a 12-week open clinical trial. A minimum adequate trial of at least 8 weeks of treatment was completed by 39 patients. Response rates were 62% (24/39) of adequately treated patients and 49% (24/49) of the whole sample. These uncontrolled findings suggest that fluoxetine is of significant benefit for a substantial proportion of obsessive-compulsive disorder patients. However, controlled trials comparing fluoxetine with placebo and other active agents are needed to confirm this, as are studies aimed to delineate fluoxetine’s full dose range, optimal length of treatment and relapse rate following discontinuation.
AB - The selective serotonin reuptake blocker fluoxetine was administered to 49 patients with obsessivecompulsive disorder in a 12-week open clinical trial. A minimum adequate trial of at least 8 weeks of treatment was completed by 39 patients. Response rates were 62% (24/39) of adequately treated patients and 49% (24/49) of the whole sample. These uncontrolled findings suggest that fluoxetine is of significant benefit for a substantial proportion of obsessive-compulsive disorder patients. However, controlled trials comparing fluoxetine with placebo and other active agents are needed to confirm this, as are studies aimed to delineate fluoxetine’s full dose range, optimal length of treatment and relapse rate following discontinuation.
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M3 - Article
C2 - 2687337
AN - SCOPUS:0024847610
SN - 0271-0749
VL - 9
SP - 423
EP - 427
JO - Journal of Clinical Psychopharmacology
JF - Journal of Clinical Psychopharmacology
IS - 6
ER -
