The selective serotonin reuptake blocker fluoxetine was administered to 49 patients with obsessivecompulsive disorder in a 12-week open clinical trial. A minimum adequate trial of at least 8 weeks of treatment was completed by 39 patients. Response rates were 62% (24/39) of adequately treated patients and 49% (24/49) of the whole sample. These uncontrolled findings suggest that fluoxetine is of significant benefit for a substantial proportion of obsessive-compulsive disorder patients. However, controlled trials comparing fluoxetine with placebo and other active agents are needed to confirm this, as are studies aimed to delineate fluoxetine’s full dose range, optimal length of treatment and relapse rate following discontinuation.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Clinical Psychopharmacology|
|State||Published - Dec 1989|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)