Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance

James R. Ewing, Craig A. Branch, Susan C. Fagan, J. A. Helpern, Robert T. Simkins, Shazad M. Butt, K. M. Welch

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We employed fluorocarbon-23 (trifluoromethane) as a nuclear magnetic resonance gaseous indicator of cerebral blood flow in seven cats. Pulsed inhalation of this indicator and switching between two coils allowed the acquisition of both an arterial input and a cerebral response function, making possible multicompartmental curve fits to cerebral uptake and clearance data. The brain: blood partition coefficient for trifluoromethane was 0.9 for both gray and white matter. Fast-compartment blood flows were normal and showed appropriate CO<inf>2</inf> reactivity. Slow-compartment blood flows did not demonstrate CO<inf>2</inf> reactivity, probably because cranial as well as white-matter blood flows were lumped together in the slow compartment Although cerebral blood flow was stable during administration of 60% trifluoromethane, the compound did prove to be a mild cardiac sensitizer to epinephrine in five cats.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalStroke
Volume21
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Fluorocarbons
Cats
Magnetic Resonance Spectroscopy
Inhalation
Epinephrine
Brain
fluoroform

Keywords

  • Cats
  • Cerebral blood flow
  • Nuclear magnetic resonance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Ewing, J. R., Branch, C. A., Fagan, S. C., Helpern, J. A., Simkins, R. T., Butt, S. M., & Welch, K. M. (1990). Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance. Stroke, 21(1), 100-106.

Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance. / Ewing, James R.; Branch, Craig A.; Fagan, Susan C.; Helpern, J. A.; Simkins, Robert T.; Butt, Shazad M.; Welch, K. M.

In: Stroke, Vol. 21, No. 1, 1990, p. 100-106.

Research output: Contribution to journalArticle

Ewing, JR, Branch, CA, Fagan, SC, Helpern, JA, Simkins, RT, Butt, SM & Welch, KM 1990, 'Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance', Stroke, vol. 21, no. 1, pp. 100-106.
Ewing JR, Branch CA, Fagan SC, Helpern JA, Simkins RT, Butt SM et al. Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance. Stroke. 1990;21(1):100-106.
Ewing, James R. ; Branch, Craig A. ; Fagan, Susan C. ; Helpern, J. A. ; Simkins, Robert T. ; Butt, Shazad M. ; Welch, K. M. / Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance. In: Stroke. 1990 ; Vol. 21, No. 1. pp. 100-106.
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