Fluorescent in situ hybridization assessment of chromosome 7 copy number in uncultured lung and kidney cells

Rizwan Naeem, Kevin Donovan, Joseph M. Corson, Jonathan A. Fletcher

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Trisomy 7 is common in cells cultured from nonneoplastic lung and kidney tissues, but the frequency of trisomy 7 in uncultured lung and kidney has not been determined. In this study, we used fluorescent in situ hybridization (FISH) to assess chromosome 7 copy number in uncultured interphase nuclei from lung and kidney specimens. All specimens had low level mosaicism for trisomy 7 (1.5-5.25%), but control experiments indicated a potential wide margin of error in quantifying these events.

Original languageEnglish (US)
Pages (from-to)100-102
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume66
Issue number2
DOIs
StatePublished - Apr 1993
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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