TY - JOUR
T1 - Fluorescent in situ hybridization assessment of chromosome 7 copy number in uncultured lung and kidney cells
AU - Naeem, Rizwan
AU - Donovan, Kevin
AU - Corson, Joseph M.
AU - Fletcher, Jonathan A.
PY - 1993/4
Y1 - 1993/4
N2 - Trisomy 7 is common in cells cultured from nonneoplastic lung and kidney tissues, but the frequency of trisomy 7 in uncultured lung and kidney has not been determined. In this study, we used fluorescent in situ hybridization (FISH) to assess chromosome 7 copy number in uncultured interphase nuclei from lung and kidney specimens. All specimens had low level mosaicism for trisomy 7 (1.5-5.25%), but control experiments indicated a potential wide margin of error in quantifying these events.
AB - Trisomy 7 is common in cells cultured from nonneoplastic lung and kidney tissues, but the frequency of trisomy 7 in uncultured lung and kidney has not been determined. In this study, we used fluorescent in situ hybridization (FISH) to assess chromosome 7 copy number in uncultured interphase nuclei from lung and kidney specimens. All specimens had low level mosaicism for trisomy 7 (1.5-5.25%), but control experiments indicated a potential wide margin of error in quantifying these events.
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U2 - 10.1016/0165-4608(93)90235-E
DO - 10.1016/0165-4608(93)90235-E
M3 - Article
C2 - 8500094
AN - SCOPUS:0027168650
SN - 0165-4608
VL - 66
SP - 100
EP - 102
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
