TY - JOUR
T1 - Flavonoids targeting NRF2 in neurodegenerative disorders
AU - Khan, Haroon
AU - Tundis, Rosa
AU - Ullah, Hammad
AU - Aschner, Michael
AU - Belwal, Tarun
AU - Mirzaei, Hamed
AU - Akkol, Esra Kupeli
N1 - Funding Information:
MA was supported in part by grants from the National Institute of Environmental Health Science ( NIEHS ) R01ES07331 and R01ES10563 .
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/12
Y1 - 2020/12
N2 - Neurodegenerative disorders are characterized by progressive loss of neurons. To date, no efficacious therapies exist for these disorders, and current therapies provide only symptomatic relief. The neuroprotective effects of natural compounds have been reported in several neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) amyotrophic lateral sclerosis (ALS), cerebral ischemia and brain tumors. Flavonoids are the most widely studied natural products for the prevention and treatment of neurodegenerative disorders. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) represents a complex gene regulated cytoprotective pathway. Several natural compounds have been identified as Nrf2 regulators in various chronic disorders, including carcinogenic, liver ailments, inflammatory conditions, neurodegeneration, diabetes and cardiotoxicities. The current review focuses on Nrf2 targeting by flavonoids in the prevention and treatment of neurodegenerative disorders, addressing the most contemporary information available on this timely subject.
AB - Neurodegenerative disorders are characterized by progressive loss of neurons. To date, no efficacious therapies exist for these disorders, and current therapies provide only symptomatic relief. The neuroprotective effects of natural compounds have been reported in several neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) amyotrophic lateral sclerosis (ALS), cerebral ischemia and brain tumors. Flavonoids are the most widely studied natural products for the prevention and treatment of neurodegenerative disorders. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) represents a complex gene regulated cytoprotective pathway. Several natural compounds have been identified as Nrf2 regulators in various chronic disorders, including carcinogenic, liver ailments, inflammatory conditions, neurodegeneration, diabetes and cardiotoxicities. The current review focuses on Nrf2 targeting by flavonoids in the prevention and treatment of neurodegenerative disorders, addressing the most contemporary information available on this timely subject.
KW - Flavonoids
KW - Neurodegenrative disorders
KW - Neuroprotection
KW - Nrf2
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U2 - 10.1016/j.fct.2020.111817
DO - 10.1016/j.fct.2020.111817
M3 - Review article
C2 - 33069760
AN - SCOPUS:85092896797
SN - 0278-6915
VL - 146
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 111817
ER -
