Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

Medicine & Life Sciences

• flavokawain B 95%
• Bortezomib 57%
• Prostatic Neoplasms 37%
• Proteins 17%
• Growth 6%
• Cell Line 5%
• Kava 5%
• Hot Temperature 5%
• Down-Regulation 4%
• Western Blotting 4%
• benzyloxycarbonylleucyl-leucyl-leucine aldehyde 4%
• Apoptosis 4%
• Proteasome Inhibitors 4%
• Ubiquitin-Protein Ligases 3%
• Castration 3%
• Enzymes 3%
• Proteasome Endopeptidase Complex 3%
• Ubiquitin 3%
• Immunoprecipitation 3%
• In Vitro Techniques 2%
• Small Interfering RNA 2%
• Up-Regulation 2%
• Enzyme-Linked Immunosorbent Assay 2%
• Antibodies 1%
• Neoplasms 1%
• Therapeutics 0%

Chemical Compounds

• Flavokawain B 100%
• Bortezomib 78%
• Protein 19%
• Western Blotting 9%
• Apoptosis Inducer 5%
• Proteasome Inhibitor 5%
• Apoptosis Induction 5%
• Cell Growth Inhibition 5%
• Silencing RNA 4%
• Resistance 2%