Flaviviruses

Braking the entering

Theodore C. Pierson, Margaret Kielian

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement on the virion at different steps of the virus entry/membrane fusion process. When combined with an increasingly clear (albeit still incomplete) view of the cell biology of virus entry, these advances suggest new antiviral strategies. Indeed, inhibitors that target cellular and viral processes involved in entry show promise as powerful tools to study this critical step of the viral lifecycle, and with luck, may ultimately lead to therapeutic advances.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalCurrent Opinion in Virology
Volume3
Issue number1
DOIs
StatePublished - Feb 2013

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Flavivirus
Virus Internalization
Virion
Virus Attachment
Cell Fusion
Antiviral Agents
Cell Biology
Proteins
Membranes
Therapeutics

ASJC Scopus subject areas

  • Virology

Cite this

Flaviviruses : Braking the entering. / Pierson, Theodore C.; Kielian, Margaret.

In: Current Opinion in Virology, Vol. 3, No. 1, 02.2013, p. 3-12.

Research output: Contribution to journalArticle

Pierson, Theodore C. ; Kielian, Margaret. / Flaviviruses : Braking the entering. In: Current Opinion in Virology. 2013 ; Vol. 3, No. 1. pp. 3-12.
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