Abstract
Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement on the virion at different steps of the virus entry/membrane fusion process. When combined with an increasingly clear (albeit still incomplete) view of the cell biology of virus entry, these advances suggest new antiviral strategies. Indeed, inhibitors that target cellular and viral processes involved in entry show promise as powerful tools to study this critical step of the viral lifecycle, and with luck, may ultimately lead to therapeutic advances.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-12 |
| Number of pages | 10 |
| Journal | Current Opinion in Virology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2013 |
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ASJC Scopus subject areas
- Virology
Cite this
Flaviviruses : Braking the entering. / Pierson, Theodore C.; Kielian, Margaret.
In: Current Opinion in Virology, Vol. 3, No. 1, 02.2013, p. 3-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Flaviviruses
T2 - Braking the entering
AU - Pierson, Theodore C.
AU - Kielian, Margaret
PY - 2013/2
Y1 - 2013/2
N2 - Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement on the virion at different steps of the virus entry/membrane fusion process. When combined with an increasingly clear (albeit still incomplete) view of the cell biology of virus entry, these advances suggest new antiviral strategies. Indeed, inhibitors that target cellular and viral processes involved in entry show promise as powerful tools to study this critical step of the viral lifecycle, and with luck, may ultimately lead to therapeutic advances.
AB - Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement on the virion at different steps of the virus entry/membrane fusion process. When combined with an increasingly clear (albeit still incomplete) view of the cell biology of virus entry, these advances suggest new antiviral strategies. Indeed, inhibitors that target cellular and viral processes involved in entry show promise as powerful tools to study this critical step of the viral lifecycle, and with luck, may ultimately lead to therapeutic advances.
UR - http://www.scopus.com/inward/record.url?scp=84874650957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874650957&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2012.12.001
DO - 10.1016/j.coviro.2012.12.001
M3 - Article
C2 - 23352692
AN - SCOPUS:84874650957
VL - 3
SP - 3
EP - 12
JO - Current Opinion in Virology
JF - Current Opinion in Virology
SN - 1879-6257
IS - 1
ER -