TY - JOUR
T1 - Flaviviruses
T2 - Braking the entering
AU - Pierson, Theodore C.
AU - Kielian, Margaret
N1 - Funding Information:
Work in the authors’ laboratories was supported by the intramural program of the National Institute of Allergy and Infectious Disease (TCP) , and by National Institutes of Health grants GM057454 , AI075647 , and U54AI057158-Lipkin (MK). The authors wish to thank Dr. Heather Hickman and members of our laboratories for critical evaluation of this review. We would like to thank Ethan Tyler (NIH/OD) and Phong Lee (NIAID, NIH) for assistance with preparation of the figures. We acknowledge the important contributions of those researchers whose work was not fully cited due to space limitations.
PY - 2013/2
Y1 - 2013/2
N2 - Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement on the virion at different steps of the virus entry/membrane fusion process. When combined with an increasingly clear (albeit still incomplete) view of the cell biology of virus entry, these advances suggest new antiviral strategies. Indeed, inhibitors that target cellular and viral processes involved in entry show promise as powerful tools to study this critical step of the viral lifecycle, and with luck, may ultimately lead to therapeutic advances.
AB - Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement on the virion at different steps of the virus entry/membrane fusion process. When combined with an increasingly clear (albeit still incomplete) view of the cell biology of virus entry, these advances suggest new antiviral strategies. Indeed, inhibitors that target cellular and viral processes involved in entry show promise as powerful tools to study this critical step of the viral lifecycle, and with luck, may ultimately lead to therapeutic advances.
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U2 - 10.1016/j.coviro.2012.12.001
DO - 10.1016/j.coviro.2012.12.001
M3 - Review article
C2 - 23352692
AN - SCOPUS:84874650957
VL - 3
SP - 3
EP - 12
JO - Current Opinion in Virology
JF - Current Opinion in Virology
SN - 1879-6257
IS - 1
ER -