TY - JOUR
T1 - Five percent carbon dioxide challenge
T2 - Valid analogue and marker of panic disorder?
AU - Sanderson, William C.
AU - Wetzler, Scott
PY - 1990/4/1
Y1 - 1990/4/1
N2 - The administration of 5% carbon dioxide (CO2) to patients with panic disorder (PD) induces a behavioral response similar to a naturally occurring panic attack. This article reviews the literature on the nature and incidence of this response. We conclude that the 5% CO2 challenge test is a valid and useful laboratory analogue of naturally occurring panic attacks, and shows promise as a marker to identify a subset of PD patients. Though further research on reliability, validity, and dose-response effects must be conducted, the CO2 challenge test provides important information regarding the phenomenology of panic states.
AB - The administration of 5% carbon dioxide (CO2) to patients with panic disorder (PD) induces a behavioral response similar to a naturally occurring panic attack. This article reviews the literature on the nature and incidence of this response. We conclude that the 5% CO2 challenge test is a valid and useful laboratory analogue of naturally occurring panic attacks, and shows promise as a marker to identify a subset of PD patients. Though further research on reliability, validity, and dose-response effects must be conducted, the CO2 challenge test provides important information regarding the phenomenology of panic states.
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U2 - 10.1016/0006-3223(90)90584-O
DO - 10.1016/0006-3223(90)90584-O
M3 - Article
C2 - 2109638
AN - SCOPUS:0025306114
SN - 0006-3223
VL - 27
SP - 689
EP - 701
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 7
ER -