TY - JOUR
T1 - First-trimester 3-dimensional power Doppler of the uteroplacental circulation space
T2 - A potential screening method for preeclampsia
AU - Dar, Pe'Er
AU - Gebb, Juliana
AU - Reimers, Laura
AU - Bernstein, Peter S.
AU - Chazotte, Cynthia
AU - Merkatz, Irwin R.
N1 - Funding Information:
This study was supported in part by a grant from the Federico Foundation .
PY - 2010/9
Y1 - 2010/9
N2 - Objective: The objective of the study was to compare 3-dimensional power Doppler (3DPD) of the uteroplacental circulation space (UPCS) in the first trimester between women who develop preeclampsia (PEC) and those who do not and to assess the 3DPD method as a screening tool for PEC. Study Design: This was a prospective observational study of singleton pregnancies at 10 weeks 4 days to 13 weeks 6 days. The 3DPD indices, vascularization index (VI), flow index (FI), and vascularization flow index (VFI), were determined on a UPSC sphere biopsy with the virtual organ computer-aided analysis (VOCAL) program. Results: Of 277 women enrolled, 24 developed PEC. The 3DPD indices were lower in women who developed PEC. The area under the receiver-operating characteristics curve for the prediction of PEC was 78.9%, 77.6%, and 79.6% for VI, FI, and VFI, respectively. Conclusion: Patients who develop PEC have lower 3DPD indices of their UPCS during the first trimester. Our findings suggest that this ultrasonographic tool has the potential to predict the development of PEC.
AB - Objective: The objective of the study was to compare 3-dimensional power Doppler (3DPD) of the uteroplacental circulation space (UPCS) in the first trimester between women who develop preeclampsia (PEC) and those who do not and to assess the 3DPD method as a screening tool for PEC. Study Design: This was a prospective observational study of singleton pregnancies at 10 weeks 4 days to 13 weeks 6 days. The 3DPD indices, vascularization index (VI), flow index (FI), and vascularization flow index (VFI), were determined on a UPSC sphere biopsy with the virtual organ computer-aided analysis (VOCAL) program. Results: Of 277 women enrolled, 24 developed PEC. The 3DPD indices were lower in women who developed PEC. The area under the receiver-operating characteristics curve for the prediction of PEC was 78.9%, 77.6%, and 79.6% for VI, FI, and VFI, respectively. Conclusion: Patients who develop PEC have lower 3DPD indices of their UPCS during the first trimester. Our findings suggest that this ultrasonographic tool has the potential to predict the development of PEC.
KW - 3-dimensional power Doppler
KW - preeclampsia
KW - screening tool
KW - uteroplacental circulation space
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U2 - 10.1016/j.ajog.2010.06.006
DO - 10.1016/j.ajog.2010.06.006
M3 - Article
C2 - 20643389
AN - SCOPUS:77956342317
SN - 0002-9378
VL - 203
SP - 238.e1-238.e7
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -