First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study

Geralyn Lambert-Messerlian, Monica McClain, James E. Haddow, Glenn E. Palomaki, Jacob A. Canick, Jane Cleary-Goldman, Fergal D. Malone, T. Flint Porter, David A. Nyberg, Peter Bernstein, Mary E. D'Alton

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Objective: The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies. Study Design: TSH, free T4, and thyroid antibodies were measured in paired sera from 9562 women in the FaSTER trial of Down syndrome screening. Results: The median first trimester TSH (1.05 mIU/L) is lower than the second (1.23 mIU/L); and 98th centile is higher (4.15 vs 3.77 mIU/L). Within-woman paired TSH correlations are moderately strong (r2 = 0.64). Among women with first trimester TSH values above the 98th centile, second trimester values are over the 95th centile in 68%. Median first trimester free T4 values (1.10 ng/dL) are higher than second (1.01 ng/dL). Paired free T4 measurements correlate weakly (r2 = 0.23). Among women with first trimester free T4 values below the 2nd centile, second trimester values are below the 5th centile in 32%. Antibody measurements correlate strongly between trimesters (thyroperoxidase r2 = 0.79, thyroglobulin r2 = 0.83). Conclusion: TSH and free T4 measurements require gestation-specific reference ranges.

Original languageEnglish (US)
Pages (from-to)62.e1-62.e6
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number1
DOIs
StatePublished - Jul 2008

Keywords

  • T4
  • TSH
  • antibodies
  • gestational ranges

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study'. Together they form a unique fingerprint.

  • Cite this

    Lambert-Messerlian, G., McClain, M., Haddow, J. E., Palomaki, G. E., Canick, J. A., Cleary-Goldman, J., Malone, F. D., Porter, T. F., Nyberg, D. A., Bernstein, P., & D'Alton, M. E. (2008). First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. American Journal of Obstetrics and Gynecology, 199(1), 62.e1-62.e6. https://doi.org/10.1016/j.ajog.2007.12.003