First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study

Geralyn Lambert-Messerlian, Monica McClain, James E. Haddow, Glenn E. Palomaki, Jacob A. Canick, Jane Cleary-Goldman, Fergal D. Malone, T. Flint Porter, David A. Nyberg, Peter S. Bernstein, Mary E. D'Alton

Research output: Contribution to journalArticle

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Abstract

Objective: The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies. Study Design: TSH, free T4, and thyroid antibodies were measured in paired sera from 9562 women in the FaSTER trial of Down syndrome screening. Results: The median first trimester TSH (1.05 mIU/L) is lower than the second (1.23 mIU/L); and 98th centile is higher (4.15 vs 3.77 mIU/L). Within-woman paired TSH correlations are moderately strong (r2 = 0.64). Among women with first trimester TSH values above the 98th centile, second trimester values are over the 95th centile in 68%. Median first trimester free T4 values (1.10 ng/dL) are higher than second (1.01 ng/dL). Paired free T4 measurements correlate weakly (r2 = 0.23). Among women with first trimester free T4 values below the 2nd centile, second trimester values are below the 5th centile in 32%. Antibody measurements correlate strongly between trimesters (thyroperoxidase r2 = 0.79, thyroglobulin r2 = 0.83). Conclusion: TSH and free T4 measurements require gestation-specific reference ranges.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number1
DOIs
StatePublished - Jul 2008

Fingerprint

Second Pregnancy Trimester
Aneuploidy
First Pregnancy Trimester
Thyroid Hormones
Pregnant Women
Research
Antibodies
Thyroid Gland
Reference Values
Thyroglobulin
Down Syndrome
Pregnancy
Serum

Keywords

  • antibodies
  • gestational ranges
  • T4
  • TSH

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

First- and second-trimester thyroid hormone reference data in pregnant women : a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. / Lambert-Messerlian, Geralyn; McClain, Monica; Haddow, James E.; Palomaki, Glenn E.; Canick, Jacob A.; Cleary-Goldman, Jane; Malone, Fergal D.; Porter, T. Flint; Nyberg, David A.; Bernstein, Peter S.; D'Alton, Mary E.

In: American Journal of Obstetrics and Gynecology, Vol. 199, No. 1, 07.2008.

Research output: Contribution to journalArticle

Lambert-Messerlian, Geralyn ; McClain, Monica ; Haddow, James E. ; Palomaki, Glenn E. ; Canick, Jacob A. ; Cleary-Goldman, Jane ; Malone, Fergal D. ; Porter, T. Flint ; Nyberg, David A. ; Bernstein, Peter S. ; D'Alton, Mary E. / First- and second-trimester thyroid hormone reference data in pregnant women : a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 199, No. 1.
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