Fine tuning by human CD1e of lipid-specific immune responses

Federica Facciotti, Marco Cavallari, Catherine Angénieux, Luis F. Garcia-Alles, François Signorino-Gelo, Lena Angman, Martine Gilleron, Jacques Prandi, Germain Puzo, Luigi Panza, Chengfeng Xia, Peng George Wang, Paolo Dellabona, Giulia Casorati, Steven A. Porcelli, Henri De La Salle, Lucia Mori, Gennaro De Libero

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.

Original languageEnglish (US)
Pages (from-to)14228-14233
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number34
DOIs
StatePublished - Aug 23 2011

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Lipids
Antigen-Presenting Cells
Antigens
Sphingomonas
Glycolipids
Antigen Presentation
T-Cell Antigen Receptor
Lysosomes
Transgenic Mice

Keywords

  • CD1 restriction
  • Lipid transfer proteins
  • Natural killer T cells

ASJC Scopus subject areas

  • General

Cite this

Facciotti, F., Cavallari, M., Angénieux, C., Garcia-Alles, L. F., Signorino-Gelo, F., Angman, L., ... De Libero, G. (2011). Fine tuning by human CD1e of lipid-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14228-14233. https://doi.org/10.1073/pnas.1108809108

Fine tuning by human CD1e of lipid-specific immune responses. / Facciotti, Federica; Cavallari, Marco; Angénieux, Catherine; Garcia-Alles, Luis F.; Signorino-Gelo, François; Angman, Lena; Gilleron, Martine; Prandi, Jacques; Puzo, Germain; Panza, Luigi; Xia, Chengfeng; Wang, Peng George; Dellabona, Paolo; Casorati, Giulia; Porcelli, Steven A.; De La Salle, Henri; Mori, Lucia; De Libero, Gennaro.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 34, 23.08.2011, p. 14228-14233.

Research output: Contribution to journalArticle

Facciotti, F, Cavallari, M, Angénieux, C, Garcia-Alles, LF, Signorino-Gelo, F, Angman, L, Gilleron, M, Prandi, J, Puzo, G, Panza, L, Xia, C, Wang, PG, Dellabona, P, Casorati, G, Porcelli, SA, De La Salle, H, Mori, L & De Libero, G 2011, 'Fine tuning by human CD1e of lipid-specific immune responses', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 34, pp. 14228-14233. https://doi.org/10.1073/pnas.1108809108
Facciotti F, Cavallari M, Angénieux C, Garcia-Alles LF, Signorino-Gelo F, Angman L et al. Fine tuning by human CD1e of lipid-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America. 2011 Aug 23;108(34):14228-14233. https://doi.org/10.1073/pnas.1108809108
Facciotti, Federica ; Cavallari, Marco ; Angénieux, Catherine ; Garcia-Alles, Luis F. ; Signorino-Gelo, François ; Angman, Lena ; Gilleron, Martine ; Prandi, Jacques ; Puzo, Germain ; Panza, Luigi ; Xia, Chengfeng ; Wang, Peng George ; Dellabona, Paolo ; Casorati, Giulia ; Porcelli, Steven A. ; De La Salle, Henri ; Mori, Lucia ; De Libero, Gennaro. / Fine tuning by human CD1e of lipid-specific immune responses. In: Proceedings of the National Academy of Sciences of the United States of America. 2011 ; Vol. 108, No. 34. pp. 14228-14233.
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