Fine needle aspiration of follicular dendritic cell sarcoma in an HIV-positive man: A case report

Kiyoe Kure, Samer N. Khader, Mark J. Suhrland, Howard Ratech, Robert Grossberg, Maja H. Oktay

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Follicular dendritic cell (FDC) sarcoma is an uncommon neoplasm occurring not only in lymph nodes but also in extranodal sites. Because of an increasing number of case reports, awareness of this tumor has grown. The nature of the disease and its relation to other diseases, treatment, prognosis and immunochemistry findings are being actively studied. So far, only a limited number of cytology cases describing the fine needle aspiration (FNA) biopsy findings of FDC sarcoma have been reported. Case: A 47-year-old man had a history of hypertension and human immunodeficiency virus (HIV) infection treated with antiretroviral therapy. He developed a slowly growing, nontender right neck mass over the course of 3 years. FNA revealed sheets and thick syncytial clusters of bland cells with pale cytoplasm and indistinct cell borders, round to oval nuclei with fine or vesicular chromatin, and small nucleoli. The mass was subsequently excised. A diagnosis of FDC sarcoma was made based on the histologic appearance and the marker studies. Conclusion: The diagnosis of FDC sarcoma in FNA can be suspected if a pathologist is aware of its characteristic features. Research studies have demonstrated the presence of HIV-related FDC hyperplasia. It is likely that HIV infection may have played a role in tumor formation in this patient.

Original languageEnglish (US)
Pages (from-to)707-711
Number of pages5
JournalActa cytologica
Volume54
Issue number5
DOIs
StatePublished - Jan 1 2010

Keywords

  • Aspiration biopsy, fine-needle
  • Follicular dendritic cell sarcoma, human immunodeficiency virus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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