Fine needle aspiration of an unusual malignant mixed tumor in the parotid gland

Research output: Contribution to journalArticle

Abstract

Objective: The use of fine needle aspiration (FNA) biopsy in the triage of salivary gland tumors has been well established. The sensitivity and specificity of FNA biopsy for tumor diagnosis is generally very good. However, the diagnosis can be challenging due to the limited amount of tissue sampled, the occasional overlapping tumor morphology, and the presence of a malignant counterpart of a benign tumor. Methods: FNA biopsy was performed with ultrasound guidance. Airdried slides and alcohol-fixed slides were made for Diff-Quik staining and Papanicolaou staining, respectively. The syringes were rinsed and a cell block was prepared. The resected specimen was fixed in 10% formalin and processed by routine histology techniques. Results: We report a rare case of a salivary gland neoplasm with 2 distinct components: adenoid cystic carcinoma and pleomorphic adenoma. These 2 components are clearly identifiable in both cytological materials from fine needle aspiration and histological analysis of surgical resection. Conclusion: Pleomorphic adenoma is the most common salivary gland tumor for patients in all age groups. The characteristic cytological feature is fibrillary extracellular matrix intermixed with epithelial cells. Malignant transformation occurs in 5% to 10% of cases. Rarely, pleomorphic adenoma exists as one component of a hybrid tumor. The surgical resection will be needed in those cases. The final diagnosis relies on the combination of the clinical information, histological findings and molecular study.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalLaboratory Medicine
Volume45
Issue number2
DOIs
StatePublished - Mar 1 2014

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Malignant Mixed Tumor
Parotid Gland
Fine Needle Biopsy
Pleomorphic Adenoma
Needles
Tumors
Glandular and Epithelial Neoplasms
Biopsy
Neoplasms
Salivary Gland Neoplasms
Staining and Labeling
Adenoid Cystic Carcinoma
Triage
Syringes
Formaldehyde
Extracellular Matrix
Histology
Age Groups
Epithelial Cells
Alcohols

Keywords

  • Adenoid cystic carcinoma
  • Basaloid tumor
  • Fine needle aspiration
  • Parotid gland
  • Pleomorphic adenoma

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

@article{3bfd45bb23804741825390275e4b38c4,
title = "Fine needle aspiration of an unusual malignant mixed tumor in the parotid gland",
abstract = "Objective: The use of fine needle aspiration (FNA) biopsy in the triage of salivary gland tumors has been well established. The sensitivity and specificity of FNA biopsy for tumor diagnosis is generally very good. However, the diagnosis can be challenging due to the limited amount of tissue sampled, the occasional overlapping tumor morphology, and the presence of a malignant counterpart of a benign tumor. Methods: FNA biopsy was performed with ultrasound guidance. Airdried slides and alcohol-fixed slides were made for Diff-Quik staining and Papanicolaou staining, respectively. The syringes were rinsed and a cell block was prepared. The resected specimen was fixed in 10{\%} formalin and processed by routine histology techniques. Results: We report a rare case of a salivary gland neoplasm with 2 distinct components: adenoid cystic carcinoma and pleomorphic adenoma. These 2 components are clearly identifiable in both cytological materials from fine needle aspiration and histological analysis of surgical resection. Conclusion: Pleomorphic adenoma is the most common salivary gland tumor for patients in all age groups. The characteristic cytological feature is fibrillary extracellular matrix intermixed with epithelial cells. Malignant transformation occurs in 5{\%} to 10{\%} of cases. Rarely, pleomorphic adenoma exists as one component of a hybrid tumor. The surgical resection will be needed in those cases. The final diagnosis relies on the combination of the clinical information, histological findings and molecular study.",
keywords = "Adenoid cystic carcinoma, Basaloid tumor, Fine needle aspiration, Parotid gland, Pleomorphic adenoma",
author = "Xiu Yang and Cole, {Adam M.} and Oktay, {Maja H.} and Smith, {Richard V.} and Antonio Cajigas and Khader, {Samer N.}",
year = "2014",
month = "3",
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doi = "10.1309/LMEKYOLQ2J5ZOO7O",
language = "English (US)",
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pages = "141--146",
journal = "Laboratory Medicine",
issn = "0007-5027",
publisher = "American Society of Clinical Pathologists",
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TY - JOUR

T1 - Fine needle aspiration of an unusual malignant mixed tumor in the parotid gland

AU - Yang, Xiu

AU - Cole, Adam M.

AU - Oktay, Maja H.

AU - Smith, Richard V.

AU - Cajigas, Antonio

AU - Khader, Samer N.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Objective: The use of fine needle aspiration (FNA) biopsy in the triage of salivary gland tumors has been well established. The sensitivity and specificity of FNA biopsy for tumor diagnosis is generally very good. However, the diagnosis can be challenging due to the limited amount of tissue sampled, the occasional overlapping tumor morphology, and the presence of a malignant counterpart of a benign tumor. Methods: FNA biopsy was performed with ultrasound guidance. Airdried slides and alcohol-fixed slides were made for Diff-Quik staining and Papanicolaou staining, respectively. The syringes were rinsed and a cell block was prepared. The resected specimen was fixed in 10% formalin and processed by routine histology techniques. Results: We report a rare case of a salivary gland neoplasm with 2 distinct components: adenoid cystic carcinoma and pleomorphic adenoma. These 2 components are clearly identifiable in both cytological materials from fine needle aspiration and histological analysis of surgical resection. Conclusion: Pleomorphic adenoma is the most common salivary gland tumor for patients in all age groups. The characteristic cytological feature is fibrillary extracellular matrix intermixed with epithelial cells. Malignant transformation occurs in 5% to 10% of cases. Rarely, pleomorphic adenoma exists as one component of a hybrid tumor. The surgical resection will be needed in those cases. The final diagnosis relies on the combination of the clinical information, histological findings and molecular study.

AB - Objective: The use of fine needle aspiration (FNA) biopsy in the triage of salivary gland tumors has been well established. The sensitivity and specificity of FNA biopsy for tumor diagnosis is generally very good. However, the diagnosis can be challenging due to the limited amount of tissue sampled, the occasional overlapping tumor morphology, and the presence of a malignant counterpart of a benign tumor. Methods: FNA biopsy was performed with ultrasound guidance. Airdried slides and alcohol-fixed slides were made for Diff-Quik staining and Papanicolaou staining, respectively. The syringes were rinsed and a cell block was prepared. The resected specimen was fixed in 10% formalin and processed by routine histology techniques. Results: We report a rare case of a salivary gland neoplasm with 2 distinct components: adenoid cystic carcinoma and pleomorphic adenoma. These 2 components are clearly identifiable in both cytological materials from fine needle aspiration and histological analysis of surgical resection. Conclusion: Pleomorphic adenoma is the most common salivary gland tumor for patients in all age groups. The characteristic cytological feature is fibrillary extracellular matrix intermixed with epithelial cells. Malignant transformation occurs in 5% to 10% of cases. Rarely, pleomorphic adenoma exists as one component of a hybrid tumor. The surgical resection will be needed in those cases. The final diagnosis relies on the combination of the clinical information, histological findings and molecular study.

KW - Adenoid cystic carcinoma

KW - Basaloid tumor

KW - Fine needle aspiration

KW - Parotid gland

KW - Pleomorphic adenoma

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