Filovirus entry into susceptible cells

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Filoviruses cause highly lethal zoonotic infections in humans and nonhuman primates. The filamentous nucleocapsid core of filovirus virions is enveloped by a host-derived lipid bilayer, in which are embedded trimers of the viral glycoprotein (GP). GP is both sufficient and necessary for filovirus entry into susceptible target cells. Intense research in the last couple of decades has greatly increased our understanding of how these viruses exploit cellular pathways to enter cells and initiate infection. Virions are taken up by a macropinocytosislike process and trafficked to endo/lysosomes where endosomal cysteine proteases prime the viral GP to bind to the essential endosomal receptor, Niemann-Pick C1 (NPC1). After engaging NPC1, viral GP is proposed to undergo extensive conformational changes that lead to fusion of the viral envelope with a cellular membrane, thereby releasing the viral genome into the cytoplasm. This chapter reviews our current understanding of the filovirus entry mechanism, while emphasizing important unanswered questions in the field.

Original languageEnglish (US)
Title of host publicationBiology and Pathogenesis of Rhabdo- and Filoviruses
PublisherWorld Scientific Publishing Co.
Pages487-514
Number of pages28
ISBN (Electronic)9789814635349
ISBN (Print)9789814635332
DOIs
StatePublished - Jan 1 2014

Fingerprint

Glycoproteins
Virion
Nucleocapsid
Cysteine Proteases
Viral Genome
Zoonoses
Lipid Bilayers
Lysosomes
Primates
Cytoplasm
Viruses
Membranes
Infection
Research

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Jangra, R., Mittler, E-M., & Chandran, K. (2014). Filovirus entry into susceptible cells. In Biology and Pathogenesis of Rhabdo- and Filoviruses (pp. 487-514). World Scientific Publishing Co.. https://doi.org/10.1142/9789814635349_0019

Filovirus entry into susceptible cells. / Jangra, Rohit; Mittler, Eva-Maria; Chandran, Kartik.

Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., 2014. p. 487-514.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jangra, R, Mittler, E-M & Chandran, K 2014, Filovirus entry into susceptible cells. in Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., pp. 487-514. https://doi.org/10.1142/9789814635349_0019
Jangra R, Mittler E-M, Chandran K. Filovirus entry into susceptible cells. In Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co. 2014. p. 487-514 https://doi.org/10.1142/9789814635349_0019
Jangra, Rohit ; Mittler, Eva-Maria ; Chandran, Kartik. / Filovirus entry into susceptible cells. Biology and Pathogenesis of Rhabdo- and Filoviruses. World Scientific Publishing Co., 2014. pp. 487-514
@inbook{f73c2a30d2a349829b75e31e7137223e,
title = "Filovirus entry into susceptible cells",
abstract = "Filoviruses cause highly lethal zoonotic infections in humans and nonhuman primates. The filamentous nucleocapsid core of filovirus virions is enveloped by a host-derived lipid bilayer, in which are embedded trimers of the viral glycoprotein (GP). GP is both sufficient and necessary for filovirus entry into susceptible target cells. Intense research in the last couple of decades has greatly increased our understanding of how these viruses exploit cellular pathways to enter cells and initiate infection. Virions are taken up by a macropinocytosislike process and trafficked to endo/lysosomes where endosomal cysteine proteases prime the viral GP to bind to the essential endosomal receptor, Niemann-Pick C1 (NPC1). After engaging NPC1, viral GP is proposed to undergo extensive conformational changes that lead to fusion of the viral envelope with a cellular membrane, thereby releasing the viral genome into the cytoplasm. This chapter reviews our current understanding of the filovirus entry mechanism, while emphasizing important unanswered questions in the field.",
author = "Rohit Jangra and Eva-Maria Mittler and Kartik Chandran",
year = "2014",
month = "1",
day = "1",
doi = "10.1142/9789814635349_0019",
language = "English (US)",
isbn = "9789814635332",
pages = "487--514",
booktitle = "Biology and Pathogenesis of Rhabdo- and Filoviruses",
publisher = "World Scientific Publishing Co.",

}

TY - CHAP

T1 - Filovirus entry into susceptible cells

AU - Jangra, Rohit

AU - Mittler, Eva-Maria

AU - Chandran, Kartik

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Filoviruses cause highly lethal zoonotic infections in humans and nonhuman primates. The filamentous nucleocapsid core of filovirus virions is enveloped by a host-derived lipid bilayer, in which are embedded trimers of the viral glycoprotein (GP). GP is both sufficient and necessary for filovirus entry into susceptible target cells. Intense research in the last couple of decades has greatly increased our understanding of how these viruses exploit cellular pathways to enter cells and initiate infection. Virions are taken up by a macropinocytosislike process and trafficked to endo/lysosomes where endosomal cysteine proteases prime the viral GP to bind to the essential endosomal receptor, Niemann-Pick C1 (NPC1). After engaging NPC1, viral GP is proposed to undergo extensive conformational changes that lead to fusion of the viral envelope with a cellular membrane, thereby releasing the viral genome into the cytoplasm. This chapter reviews our current understanding of the filovirus entry mechanism, while emphasizing important unanswered questions in the field.

AB - Filoviruses cause highly lethal zoonotic infections in humans and nonhuman primates. The filamentous nucleocapsid core of filovirus virions is enveloped by a host-derived lipid bilayer, in which are embedded trimers of the viral glycoprotein (GP). GP is both sufficient and necessary for filovirus entry into susceptible target cells. Intense research in the last couple of decades has greatly increased our understanding of how these viruses exploit cellular pathways to enter cells and initiate infection. Virions are taken up by a macropinocytosislike process and trafficked to endo/lysosomes where endosomal cysteine proteases prime the viral GP to bind to the essential endosomal receptor, Niemann-Pick C1 (NPC1). After engaging NPC1, viral GP is proposed to undergo extensive conformational changes that lead to fusion of the viral envelope with a cellular membrane, thereby releasing the viral genome into the cytoplasm. This chapter reviews our current understanding of the filovirus entry mechanism, while emphasizing important unanswered questions in the field.

UR - http://www.scopus.com/inward/record.url?scp=84988568693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988568693&partnerID=8YFLogxK

U2 - 10.1142/9789814635349_0019

DO - 10.1142/9789814635349_0019

M3 - Chapter

SN - 9789814635332

SP - 487

EP - 514

BT - Biology and Pathogenesis of Rhabdo- and Filoviruses

PB - World Scientific Publishing Co.

ER -