Filovirus entry into cells - New insights

Emily Happy Miller, Kartik Chandran

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Filoviruses are hemorrhagic fever-causing agents that produce enveloped virions with a filamentous morphology. The viral surface glycoprotein, GP, orchestrates the surprisingly complex process by which filoviruses gain access to the cytoplasm of their host cells. GP mediates viral attachment to cells through multiple, redundant interactions with cell-surface factors. GP then induces virion internalization by a process that resembles cellular macropinocytosis. Within the endo/lysosomal pathway, GP undergoes a series of structural rearrangements, controlled by interactions with host factors, that prime and activate it to bring about fusion between the viral and cellular lipid bilayers. Membrane fusion delivers the viral nucleocapsid core into the cytoplasm, which is the site of filovirus replication. This review summarizes our understanding of the filovirus entry mechanism, with emphasis on recent findings.

Original languageEnglish (US)
Pages (from-to)206-214
Number of pages9
JournalCurrent Opinion in Virology
Volume2
Issue number2
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Virology

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