TY - JOUR
T1 - Filovirus entry into cells - New insights
AU - Miller, Emily Happy
AU - Chandran, Kartik
N1 - Funding Information:
We thank John M. Dye and Erica O. Saphire for comments and discussion, and apologize in advance to colleagues whose work could not be cited owing to space limitations. The authors are supported by National Institutes of Health grant R01AI088027 . E.H.M. is additionally supported by the NIH-funded training program T32 GM007288 at the Albert Einstein College of Medicine.
PY - 2012/4
Y1 - 2012/4
N2 - Filoviruses are hemorrhagic fever-causing agents that produce enveloped virions with a filamentous morphology. The viral surface glycoprotein, GP, orchestrates the surprisingly complex process by which filoviruses gain access to the cytoplasm of their host cells. GP mediates viral attachment to cells through multiple, redundant interactions with cell-surface factors. GP then induces virion internalization by a process that resembles cellular macropinocytosis. Within the endo/lysosomal pathway, GP undergoes a series of structural rearrangements, controlled by interactions with host factors, that prime and activate it to bring about fusion between the viral and cellular lipid bilayers. Membrane fusion delivers the viral nucleocapsid core into the cytoplasm, which is the site of filovirus replication. This review summarizes our understanding of the filovirus entry mechanism, with emphasis on recent findings.
AB - Filoviruses are hemorrhagic fever-causing agents that produce enveloped virions with a filamentous morphology. The viral surface glycoprotein, GP, orchestrates the surprisingly complex process by which filoviruses gain access to the cytoplasm of their host cells. GP mediates viral attachment to cells through multiple, redundant interactions with cell-surface factors. GP then induces virion internalization by a process that resembles cellular macropinocytosis. Within the endo/lysosomal pathway, GP undergoes a series of structural rearrangements, controlled by interactions with host factors, that prime and activate it to bring about fusion between the viral and cellular lipid bilayers. Membrane fusion delivers the viral nucleocapsid core into the cytoplasm, which is the site of filovirus replication. This review summarizes our understanding of the filovirus entry mechanism, with emphasis on recent findings.
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U2 - 10.1016/j.coviro.2012.02.015
DO - 10.1016/j.coviro.2012.02.015
M3 - Review article
C2 - 22445965
AN - SCOPUS:84859514186
SN - 1879-6257
VL - 2
SP - 206
EP - 214
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 2
ER -