Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.
|Original language||English (US)|
|Number of pages||8|
|Journal||Nature Reviews Molecular Cell Biology|
|State||Published - Feb 1 2001|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology