Filamins as integrators of cell mechanics and signalling

Thomas P. Stossel; John Condeelis; Lynn Cooley; John H. Hartwig; Angelika Noegel; Michael Schleicher; Sandor S. Shapiro

doi:10.1038/35052082

Filamins as integrators of cell mechanics and signalling

Thomas P. Stossel, John Condeelis, Lynn Cooley, John H. Hartwig, Angelika Noegel, Michael Schleicher, Sandor S. Shapiro

Anatomy & Structural Biology

Research output: Contribution to journal › Review article › peer-review

822 Scopus citations

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

Original language	English (US)
Pages (from-to)	138-145
Number of pages	8
Journal	Nature Reviews Molecular Cell Biology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1038/35052082
State	Published - Feb 1 2001

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/35052082

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title = "Filamins as integrators of cell mechanics and signalling",

abstract = "Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.",

author = "Stossel, {Thomas P.} and John Condeelis and Lynn Cooley and Hartwig, {John H.} and Angelika Noegel and Michael Schleicher and Shapiro, {Sandor S.}",

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AU - Stossel, Thomas P.

AU - Condeelis, John

AU - Cooley, Lynn

AU - Hartwig, John H.

AU - Noegel, Angelika

AU - Schleicher, Michael

AU - Shapiro, Sandor S.

PY - 2001/2/1

Y1 - 2001/2/1

N2 - Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

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DO - 10.1038/35052082

M3 - Review article

C2 - 11252955

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JO - Nature Reviews Molecular Cell Biology

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Filamins as integrators of cell mechanics and signalling

Abstract

ASJC Scopus subject areas

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