Filamins as integrators of cell mechanics and signalling

Thomas P. Stossel, John Condeelis, Lynn Cooley, John H. Hartwig, Angelika Noegel, Michael Schleicher, Sandor S. Shapiro

Research output: Contribution to journalReview article

718 Scopus citations

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

Original languageEnglish (US)
Pages (from-to)138-145
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume2
Issue number2
DOIs
StatePublished - Feb 1 2001

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Stossel, T. P., Condeelis, J., Cooley, L., Hartwig, J. H., Noegel, A., Schleicher, M., & Shapiro, S. S. (2001). Filamins as integrators of cell mechanics and signalling. Nature Reviews Molecular Cell Biology, 2(2), 138-145. https://doi.org/10.1038/35052082