@article{679a1103c7754c52bb49d9f5985457bc,
title = "Fibroblasts in head and neck squamous cell carcinoma associated with perineural invasion have high-level nuclear yes-associated protein (YAP) expression",
abstract = "We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.",
keywords = "Fibroblast, Perineural invasion, Squamous cell carcinoma, YAP expression",
author = "Yanghua Wang and Adam Gersten and Susana Moleirinho and Gunn-Moore, {Frank J.} and Reynolds, {Paul A.} and Prystowsky, {Michael B.}",
note = "Funding Information: F{\'a}bio Rafael Augusto is a PhD Candidate in Sociology at the Instituto de Ci{\^e}ncias Sociais, Universidade de Lisboa (ICS-ULisboa) and currently holds a PhD grant from the Portuguese Foundation for Science and Technology (FCT). His doctoral research seeks to characterize and analyze food aid initiatives operating in Portugal. He had been a guest lecturer at Escola Superior de Sa{\'u}de, Instituto Polit{\'e}cnico de Santar{\'e}m (ESSS-IPSantar{\'e}m) and has been involved in two research projects (“TRANSE-AC: Social and Environmental Transition – Alternatives and Commons” supported by Programa Pessoa/FCT and “FFHT: Families and Food in Hard Times” funded by the European Research Council). He holds a MSc in Sociology: Exclusion and Social Policies and a BSc in Sociology (UBI, Universidade da Beira Interior). His research interests include food (in)security, poverty and social exclusion. Correspondence regarding this article can be addressed directly to: fabio.augusto@ics.ulisboa.pt. Funding Information: The PhD project leading to these results has received funding from the European Research Council (ERC) under the European Union{\textquoteright}s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement n° 337977 and from the Portuguese Foundation for Science and Technology (FCT) through the Human Capital Operational Programme (POCH) supported by the European Social Fund (ESF) and national funds of the Portuguese Ministry of Science, Technology and Higher Education (MCTES) with the reference SFRH/BD/130072/2017. Funding Information: 1 This expression comes from the story “Through the looking glass” by Lewis Carrol and is often used in English language. 2 This paper is based on the research carried out by the first author during his PhD in Sociology at the Instituto de Ci{\^e}ncias Sociais, Universidade de Lisboa (ICS-ULisboa), currently supported by the Portuguese Foundation for Science and Technology (FCT). Funding Information: The PhD project leading to these results has received funding from the European Research Council (ERC) under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement n? 337977 and from the Portuguese Foundation for Science and Technology (FCT) through the Human Capital Operational Programme (POCH) supported by the European Social Fund (ESF) and national funds of the Portuguese Ministry of Science, Technology and Higher Education (MCTES) with the reference SFRH/BD/130072/2017. Publisher Copyright: {\textcopyright} The Author(s) 2015.",
year = "2015",
month = oct,
day = "1",
doi = "10.1177/2374289515616972",
language = "English (US)",
volume = "2",
journal = "Academic Pathology",
issn = "2374-2895",
publisher = "SAGE Publications Ltd",
number = "4",
}