Fibroblast—Extracellular Matrix Interactions in Tissue Fibrosis

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Activated myofibroblasts are key effector cells in tissue fibrosis. Emerging evidence suggests that myofibroblasts infiltrating fibrotic tissues originate predominantly from local mesenchyme-derived populations. Alterations in the extracellular matrix network play an important role in modulating fibroblast phenotype and function. In a pro-inflammatory environment, generation of matrix fragments may induce a matrix-degrading fibroblast phenotype. Deposition of ED-A fibronectin plays an important role in myofibroblast transdifferentiation. In fibrotic tissues, the matrix is enriched with matricellular macromolecules that regulate growth factor-mediated responses and modulate protease activation. This manuscript discusses emerging concepts on the role of the extracellular matrix in regulation of fibroblast behavior.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalCurrent Pathobiology Reports
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2016

Keywords

  • Extracellular matrix
  • Fibroblast
  • Matricellular protein
  • Myofibroblast
  • Pericyte
  • Thrombospondin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology
  • Cancer Research

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