FGFR1 is required for the development of the auditory sensory epithelium

Ulla Pirvola, Jukka Ylikoski, Ras Trokovic, Jean M. Hébert, Susan K. McConnell, Juha Partanen

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Abstract

The mammalian auditory sensory epithelium, the organ of Corti, comprises the hair cells and supporting cells that are pivotal for hearing function. The origin and development of their precursors are poorly understood. Here we show that loss-of-function mutations in mouse fibroblast growth factor receptor 1 (Fgfr1) cause a dose-dependent disruption of the organ of Corti. Full inactivation of Fgfr1 in the inner ear epithelium by Foxg1-Cre-mediated deletion leads to an 85% reduction in the number of auditory hair cells. The primary cause appears to be reduced precursor cell proliferation in the early cochlear duct. Thus, during development, FGFR1 is required for the generation of the precursor pool, which gives rise to the auditory sensory epithelium. Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium.

Original languageEnglish (US)
Pages (from-to)671-680
Number of pages10
JournalNeuron
Volume35
Issue number4
DOIs
StatePublished - Aug 15 2002

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pirvola, U., Ylikoski, J., Trokovic, R., Hébert, J. M., McConnell, S. K., & Partanen, J. (2002). FGFR1 is required for the development of the auditory sensory epithelium. Neuron, 35(4), 671-680. https://doi.org/10.1016/S0896-6273(02)00824-3