TY - JOUR
T1 - FGF5 as a regulator of the hair growth cycle
T2 - Evidence from targeted and spontaneous mutations
AU - Hébert, Jean M.
AU - Rosenquist, Thomas
AU - Götz, Jürgen
AU - Martin, Gail R.
N1 - Funding Information:
Correspondence should be addressed to G. R. M. We are extremely grateful to Dr. Kevin Ward and his colleagues at the Commonwealth Scientific and Industrial Research Organization, Division of Animal Production, New South Wales, Australia, for generously providing the go/go mice used in this study. We also thank Dr. Kevin Ward, Dr. Cori Bargmann, Dr. Marc Tessier-Lavigne, and our laboratory colleagues for encouragement and critical reading of the manuscript. Drs. David Kingsley and Arthur Bertolino for helpful discussion, Dr. Alexandra Joyner for providing Rl ES cells, Dr. Dan Lowenstein for advice on isolating hippocampi, Greg Thomas for patient help in photographing the mice, and Dr. Phil Crossley and Nick Martin for help with figure production. J. M. H. wassupported byfundsfromThe Lucille P. Markey Charitable Trust (grant 8814), T. R. was supported by National Institutes of Health (NIH) postdoctoral training grant CA 09043, and J. G. was supported by a postdoctoral fellowship from the government of the Federal Republic of Germany. This work was initially supported by NIH grant ROl HD22731 to G. R. M. and subsequently by the NIH Program of Excellence in Molecular Biology (grant PO1 HL 43821), as well as by a grant from The Lucille P. Markey Charitable Trust to the Program in Biological Sciences. In accord with the rules of the International Committee for Standardized Genetic Nomenclature for Mice, the official designation of the fgf!F’ mice described here will be fgfLFun and the symbol for the angora mutation. go, will be changed to fgf?.
PY - 1994/9/23
Y1 - 1994/9/23
N2 - Fibroblast growth factor 5 (FGF5) is a secreted signaling protein. Mice homozygous for a predicted null allele of the Fgf5 gene, fgf5neo, produced by gene targeting in embryonic stem cells, have abnormally long hair. This phenotype appears identical to that of mice homozygous for the spontaneous mutation angora (go). The fgf5neo and go mutations fail to complement one another, and exon 1 of Fgf5 is deleted in DNA from go homozygotes, demonstrating that go is a mutant allele of Fgf5. Expression of Fgf5 is detected in hair follicles from wild-type mice and is localized to the outer root sheath during the anagen VI phase of the hair growth cycle. These findings provide evidence that FGF5 functions as an inhibitor of hair elongation, thus identifying a molecule whose normal function is apparently to regulate one step in the progression of the follicle through the hair growth cycle.
AB - Fibroblast growth factor 5 (FGF5) is a secreted signaling protein. Mice homozygous for a predicted null allele of the Fgf5 gene, fgf5neo, produced by gene targeting in embryonic stem cells, have abnormally long hair. This phenotype appears identical to that of mice homozygous for the spontaneous mutation angora (go). The fgf5neo and go mutations fail to complement one another, and exon 1 of Fgf5 is deleted in DNA from go homozygotes, demonstrating that go is a mutant allele of Fgf5. Expression of Fgf5 is detected in hair follicles from wild-type mice and is localized to the outer root sheath during the anagen VI phase of the hair growth cycle. These findings provide evidence that FGF5 functions as an inhibitor of hair elongation, thus identifying a molecule whose normal function is apparently to regulate one step in the progression of the follicle through the hair growth cycle.
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U2 - 10.1016/0092-8674(94)90276-3
DO - 10.1016/0092-8674(94)90276-3
M3 - Article
C2 - 7923352
AN - SCOPUS:0027931643
SN - 0092-8674
VL - 78
SP - 1017
EP - 1025
JO - Cell
JF - Cell
IS - 6
ER -