FGF signaling through FGFR1 is required for olfactory bulb morphogenesis

Jean M. Hebert, Mary Lin, Juha Partanen, Janet Rossant, Susan K. McConnell

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

During development, the embryonic telencephalon is patterned into different areas that give rise to distinct adult brain structures. Several secreted signaling molecules are expressed at putative signaling centers in the early telencephalon. In particular, Fgf8 is expressed at the anterior end of the telencephalon and is hypothesized to pattern it along the anteroposterior (AP) axis. Using a CRE/loxP genetic approach to disrupt genes in the telencephalon, we address the role of FGF signaling directly in vivo by abolishing expression of the FGF receptor Fgfr1. In the Fgfr1-deficient telencephalon, AP patterning is largely normal. However, morphological defects are observed at the anterior end of the telencephalon. Most notably, the olfactory bulbs do not form normally. Examination of the proliferation state of anterior telencephalic cells supports a model for olfactory bulb formation in which an FGF-dependent decrease in proliferation is required for initial bulb evagination. Together the results demonstrate an essential role for Fgfr1 in patterning and morphogenesis of the telencephalon.

Original languageEnglish (US)
Pages (from-to)1101-1111
Number of pages11
JournalDevelopment
Volume130
Issue number6
DOIs
StatePublished - Mar 2003

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Telencephalon
Olfactory Bulb
Morphogenesis
Fibroblast Growth Factor Receptors
Brain

Keywords

  • Cell fate
  • Cre/loxP
  • Forebrain
  • Neurogenesis
  • Patterning
  • Telencephalon

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Hebert, J. M., Lin, M., Partanen, J., Rossant, J., & McConnell, S. K. (2003). FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development, 130(6), 1101-1111. https://doi.org/10.1242/dev.00334

FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. / Hebert, Jean M.; Lin, Mary; Partanen, Juha; Rossant, Janet; McConnell, Susan K.

In: Development, Vol. 130, No. 6, 03.2003, p. 1101-1111.

Research output: Contribution to journalArticle

Hebert, JM, Lin, M, Partanen, J, Rossant, J & McConnell, SK 2003, 'FGF signaling through FGFR1 is required for olfactory bulb morphogenesis', Development, vol. 130, no. 6, pp. 1101-1111. https://doi.org/10.1242/dev.00334
Hebert, Jean M. ; Lin, Mary ; Partanen, Juha ; Rossant, Janet ; McConnell, Susan K. / FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. In: Development. 2003 ; Vol. 130, No. 6. pp. 1101-1111.
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