FGF signaling through FGFR1 is required for olfactory bulb morphogenesis

Jean M. Hébert, Mary Lin, Juha Partanen, Janet Rossant, Susan K. McConnell

Research output: Contribution to journalReview articlepeer-review

188 Scopus citations


During development, the embryonic telencephalon is patterned into different areas that give rise to distinct adult brain structures. Several secreted signaling molecules are expressed at putative signaling centers in the early telencephalon. In particular, Fgf8 is expressed at the anterior end of the telencephalon and is hypothesized to pattern it along the anteroposterior (AP) axis. Using a CRE/loxP genetic approach to disrupt genes in the telencephalon, we address the role of FGF signaling directly in vivo by abolishing expression of the FGF receptor Fgfr1. In the Fgfr1-deficient telencephalon, AP patterning is largely normal. However, morphological defects are observed at the anterior end of the telencephalon. Most notably, the olfactory bulbs do not form normally. Examination of the proliferation state of anterior telencephalic cells supports a model for olfactory bulb formation in which an FGF-dependent decrease in proliferation is required for initial bulb evagination. Together the results demonstrate an essential role for Fgfr1 in patterning and morphogenesis of the telencephalon.

Original languageEnglish (US)
Pages (from-to)1101-1111
Number of pages11
Issue number6
StatePublished - Mar 2003


  • Cell fate
  • Cre/loxP
  • Forebrain
  • Neurogenesis
  • Patterning
  • Telencephalon

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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