FGF signaling is strictly required to maintain early telencephalic precursor cell survival

Hunki Paek, Grigority Gutin, Jean M. Hébert

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

The FGF family of extracellular signaling factors has been proposed to play multiple roles in patterning the telencephalon, the precursor to the cerebrum. In this study, unlike previous ones, we effectively abolish FGF signaling in the anterior neural plate via deletion of three FGF receptor (FGFR) genes. Triple FGFR mutant mice exhibit a complete loss of the telencephalon, except the dorsal midline. Disruption of FGF signaling prior to and coincident with telencephalic induction reveals that FGFs promote telencephalic character and are strictly required to keep telencephalic cells alive. Moreover, progressively more severe truncations of the telencephalon are observed in FGFR single, double and triple mutants. Together with previous gain-of-function studies showing induction of Foxg1 expression and mirror-image duplications of the cortex by exogenous FGF8, our loss-of-function results suggest that, rather than independently patterning different areas, FGF ligands and receptors act in concert to mediate organizer activity for the whole telencephalon.

Original languageEnglish (US)
Pages (from-to)2457-2465
Number of pages9
JournalDevelopment
Volume136
Issue number14
DOIs
Publication statusPublished - Jul 15 2009

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Keywords

  • FGF receptors
  • Forebrain
  • Mouse
  • Neural patterning
  • Neural plate

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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