Fetal immunoglobulin synthesis following maternal immunosuppression

L. L. Cederqvist; I. R. Merkatz; S. D. Litwin

doi:10.1016/0002-9378(77)90653-6

Fetal immunoglobulin synthesis following maternal immunosuppression

L. L. Cederqvist, I. R. Merkatz, S. D. Litwin

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA₁ and IgA₂ subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.

Original language	English (US)
Pages (from-to)	687-690
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	129
Issue number	6
DOIs	https://doi.org/10.1016/0002-9378(77)90653-6
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/0002-9378(77)90653-6

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@article{7a6323c62c754b9cabbd3bad3b2f574e,

title = "Fetal immunoglobulin synthesis following maternal immunosuppression",

abstract = "Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.",

author = "Cederqvist, {L. L.} and Merkatz, {I. R.} and Litwin, {S. D.}",

note = "Funding Information: From the Drpartmml uf Obstetrirs and Grnecolog_v and th,· Division of Human Gene/irs, Drparlmenl of M!'dirine. The New York Hospital-Cornell Medi(fl/ Center. Nt'H' York, and the Departmmt of Ob,,tetrics and G)'llecology, C11.1e We.1lan Re.lfTlil' Universit)•, Cle<•rland. Thi.-.. ·work wrn madr possiblt) by a grant Jrvm the ~\'ational Foundation-Marrh of Dimes and was partially supported h United States Publir Hralth Sen•ia Grants .41-09239 r;nd AM-202122",

year = "1977",

doi = "10.1016/0002-9378(77)90653-6",

language = "English (US)",

volume = "129",

pages = "687--690",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "6",

}

TY - JOUR

T1 - Fetal immunoglobulin synthesis following maternal immunosuppression

AU - Cederqvist, L. L.

AU - Merkatz, I. R.

AU - Litwin, S. D.

N1 - Funding Information: From the Drpartmml uf Obstetrirs and Grnecolog_v and th,· Division of Human Gene/irs, Drparlmenl of M!'dirine. The New York Hospital-Cornell Medi(fl/ Center. Nt'H' York, and the Departmmt of Ob,,tetrics and G)'llecology, C11.1e We.1lan Re.lfTlil' Universit)•, Cle<•rland. Thi.-.. ·work wrn madr possiblt) by a grant Jrvm the ~\'ational Foundation-Marrh of Dimes and was partially supported h United States Publir Hralth Sen•ia Grants .41-09239 r;nd AM-202122

PY - 1977

Y1 - 1977

N2 - Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.

AB - Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.

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U2 - 10.1016/0002-9378(77)90653-6

DO - 10.1016/0002-9378(77)90653-6

M3 - Article

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AN - SCOPUS:0017747066

SN - 0002-9378

VL - 129

SP - 687

EP - 690

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 6

ER -

Fetal immunoglobulin synthesis following maternal immunosuppression

Abstract

ASJC Scopus subject areas

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