Fetal immunoglobulin synthesis following maternal immunosuppression

L. L. Cederqvist, I. R. Merkatz, S. D. Litwin

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.

Original languageEnglish (US)
Pages (from-to)687-690
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume129
Issue number6
DOIs
Publication statusPublished - Jan 1 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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