Fetal immunoglobulin synthesis following maternal immunosuppression

L. L. Cederqvist, Irwin R. Merkatz, S. D. Litwin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.

Original languageEnglish (US)
Pages (from-to)687-690
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume129
Issue number6
StatePublished - 1977
Externally publishedYes

Fingerprint

Immunosuppression
Immunoglobulin A
Immunoglobulins
Mothers
Immunosuppressive Agents
Fetal Blood
Immunoglobulin M
Immunoglobulin D
Azathioprine
Prednisone
Systemic Lupus Erythematosus
Kidney Transplantation
Rupture
Fetus
Immunoglobulin G
Pregnancy
Membranes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Fetal immunoglobulin synthesis following maternal immunosuppression. / Cederqvist, L. L.; Merkatz, Irwin R.; Litwin, S. D.

In: American Journal of Obstetrics and Gynecology, Vol. 129, No. 6, 1977, p. 687-690.

Research output: Contribution to journalArticle

@article{7a6323c62c754b9cabbd3bad3b2f574e,
title = "Fetal immunoglobulin synthesis following maternal immunosuppression",
abstract = "Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.",
author = "Cederqvist, {L. L.} and Merkatz, {Irwin R.} and Litwin, {S. D.}",
year = "1977",
language = "English (US)",
volume = "129",
pages = "687--690",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Fetal immunoglobulin synthesis following maternal immunosuppression

AU - Cederqvist, L. L.

AU - Merkatz, Irwin R.

AU - Litwin, S. D.

PY - 1977

Y1 - 1977

N2 - Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.

AB - Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA1 and IgA2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responded with increased synthesis of IgA and IgM following premature rupture of the membranes.

UR - http://www.scopus.com/inward/record.url?scp=0017747066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017747066&partnerID=8YFLogxK

M3 - Article

VL - 129

SP - 687

EP - 690

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -