TY - JOUR
T1 - Fetal Cortical Cells Survive in Focal Cerebral Infarct After Permanent Occlusion of the Middle Cerebral Artery in Adult Rats
AU - Hadani, Moshe
AU - Freeman, Thomas
AU - Munsiff, Amar
AU - Young, Wise
AU - Flamm, Eugene
PY - 1992
Y1 - 1992
N2 - Fetal rat cortical cells have been shown previously to survive at the periphery of cerebral infarction. The present study was designed to examine the ability of fetal cells to survive at the edge of the central core of ischemia. In three groups of 8 adult Sprague-Dawley rats, fetal cortical cells from ED 16 were stereotactically transplanted at 3 h, 24 h, and 7 days after unilateral middle cerebral artery occlusion. In 6 rats, fetal cells were transplanted by using the same coordinates, without arterial occlusion, for control. In the ischemic groups, overall graft survival was 85%, and in the control group, all grafts survived. Graft survival was determined by light microscopy. No significant difference was found in the survival of grafts transplanted at different intervals after middle cerebral artery occlusion. It is concluded that fetal cortical cells can survive in cerebral tissue undergoing severe ischemic change.
AB - Fetal rat cortical cells have been shown previously to survive at the periphery of cerebral infarction. The present study was designed to examine the ability of fetal cells to survive at the edge of the central core of ischemia. In three groups of 8 adult Sprague-Dawley rats, fetal cortical cells from ED 16 were stereotactically transplanted at 3 h, 24 h, and 7 days after unilateral middle cerebral artery occlusion. In 6 rats, fetal cells were transplanted by using the same coordinates, without arterial occlusion, for control. In the ischemic groups, overall graft survival was 85%, and in the control group, all grafts survived. Graft survival was determined by light microscopy. No significant difference was found in the survival of grafts transplanted at different intervals after middle cerebral artery occlusion. It is concluded that fetal cortical cells can survive in cerebral tissue undergoing severe ischemic change.
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U2 - 10.1089/neu.1992.9.107
DO - 10.1089/neu.1992.9.107
M3 - Article
C2 - 1404423
AN - SCOPUS:0026794902
SN - 0897-7151
VL - 9
SP - 107
EP - 112
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
IS - 2
ER -