Fetal cortical cells survive in focal cerebral infarct after permanent occlusion of the middle cerebral artery in adult rats

M. Hadani, T. Freeman, A. Munsiff, W. Young, Eugene S. Flamm

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Fetal rat cortical cells have been shown previously to survive at the periphery of cerebral infarction. The present study was designed to examine the ability of fetal cells to survive at the edge of the central core of ischemia. In three groups of 8 adult Sprague-Dawley rats, fetal cortical cells from ED 16 were stereotactically transplanted at 3 h, 24 h, and 7 days after unilateral middle cerebral artery occlusion. In 6 rats, fetal cells were transplanted by using the same coordinates, without arterial occlusion, for control. In the ischemic groups, overall graft survival was 85%, and in the control group, all grafts survived. Graft survival was determined by light microscopy. No significant difference was found in the survival of grafts transplanted at different intervals after middle cerebral artery occlusion. It is concluded that fetal cortical cells can survive in cerebral tissue undergoing severe ischemic change.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalJournal of Neurotrauma
Volume9
Issue number2
StatePublished - 1992
Externally publishedYes

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Middle Cerebral Artery Infarction
Graft Survival
Cerebral Infarction
Sprague Dawley Rats
Microscopy
Ischemia
Transplants
Light
Control Groups

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Fetal cortical cells survive in focal cerebral infarct after permanent occlusion of the middle cerebral artery in adult rats. / Hadani, M.; Freeman, T.; Munsiff, A.; Young, W.; Flamm, Eugene S.

In: Journal of Neurotrauma, Vol. 9, No. 2, 1992, p. 107-112.

Research output: Contribution to journalArticle

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