TY - JOUR
T1 - Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly Chinese
AU - Sun, Liang
AU - Franco, Oscar H.
AU - Hu, Frank B.
AU - Cai, Lu
AU - Yu, Zhijie
AU - Li, Huaixing
AU - Ye, Xingwang
AU - Qi, Qibin
AU - Wang, Jing
AU - Pan, An
AU - Liu, Yong
AU - Lin, Xu
N1 - Funding Information:
This study was supported by the Chief Scientist Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (SIBS2008006), Ministry of Science and Technology of China (973 Program, Grant 2006CB503902; Grant 2008DFA3196), the Knowledge Innovation Program Project of the Chinese Academy of Sciences (KSCX2-YW-R-73, KSCX2-YW-R-116, and KSCX1-YW-02), the National Natural Science Foundation of China (30571562), and the Shanghai-Unilever Research Development Fund (CH-2006–0941).
PY - 2008/12
Y1 - 2008/12
N2 - Context: Elevated ferritin concentrations frequently cluster with well-established risk factors of diabetes including obesity, metabolic syndrome, chronic inflammation, and altered circulating adipokines. Few studies, however, have systematically evaluated the effect of these risk factors on ferritin-diabetes association, particularly in Chinese populations. Objective: We aimed to investigate, in a middle-aged and elderly Chinese population, whether elevated ferritin concentrations are associated with higher risk of metabolic syndrome and type 2 diabetes and to what extent the associations were influenced by obesity, inflammation, and adipokines. Design and Methods: We conducted a population-based, cross-sectional survey of 3289 participants aged 50-70 yr in Beijing and Shanghai in 2005. Fasting plasma ferritin, glucose, insulin, lipid profile, glycohemoglobin, inflammatory markers, adipokines, and dietary profile were measured. Results: Median ferritin concentrations were 155.7 ng/ml for men and 111.9 ng/ml for women. After multiple adjustment, the odds ratios (ORs) were substantially higher for type 2 diabetes (OR 3.26, 95% confidence interval 2.36-4.51) and metabolic syndrome [OR 2.80 (95% confidence interval 2.24-3.49)] in the highest ferritin quartile compared with those in the lowest quartile. These associations remained significant after further adjustment for dietary factors, body mass index, inflammatory markers, and adipokines. Conclusions: Elevated circulating ferritin concentrations were associated with higher risk of type 2 diabetes and metabolic syndrome in middle-aged and elderly Chinese independent of obesity, inflammation, adipokines, and other risk factors. Our data support the crucial role of iron overload for metabolic diseases, even in a country with relatively high prevalence of iron deficiency.
AB - Context: Elevated ferritin concentrations frequently cluster with well-established risk factors of diabetes including obesity, metabolic syndrome, chronic inflammation, and altered circulating adipokines. Few studies, however, have systematically evaluated the effect of these risk factors on ferritin-diabetes association, particularly in Chinese populations. Objective: We aimed to investigate, in a middle-aged and elderly Chinese population, whether elevated ferritin concentrations are associated with higher risk of metabolic syndrome and type 2 diabetes and to what extent the associations were influenced by obesity, inflammation, and adipokines. Design and Methods: We conducted a population-based, cross-sectional survey of 3289 participants aged 50-70 yr in Beijing and Shanghai in 2005. Fasting plasma ferritin, glucose, insulin, lipid profile, glycohemoglobin, inflammatory markers, adipokines, and dietary profile were measured. Results: Median ferritin concentrations were 155.7 ng/ml for men and 111.9 ng/ml for women. After multiple adjustment, the odds ratios (ORs) were substantially higher for type 2 diabetes (OR 3.26, 95% confidence interval 2.36-4.51) and metabolic syndrome [OR 2.80 (95% confidence interval 2.24-3.49)] in the highest ferritin quartile compared with those in the lowest quartile. These associations remained significant after further adjustment for dietary factors, body mass index, inflammatory markers, and adipokines. Conclusions: Elevated circulating ferritin concentrations were associated with higher risk of type 2 diabetes and metabolic syndrome in middle-aged and elderly Chinese independent of obesity, inflammation, adipokines, and other risk factors. Our data support the crucial role of iron overload for metabolic diseases, even in a country with relatively high prevalence of iron deficiency.
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U2 - 10.1210/jc.2008-1159
DO - 10.1210/jc.2008-1159
M3 - Article
C2 - 18796516
AN - SCOPUS:57349181284
SN - 0021-972X
VL - 93
SP - 4690
EP - 4696
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 12
ER -