Feline immunodeficiency virus (FIV) in wild Pallas' cats

Meredith A. Brown, Bariushaa Munkhtsog, Jennifer L. Troyer, Steve Ross, Rani Sellers, Amanda E. Fine, William F. Swanson, Melody E. Roelke, Stephen J. O'Brien

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalVeterinary Immunology and Immunopathology
Volume134
Issue number1-2
DOIs
StatePublished - Mar 15 2010

Fingerprint

Feline Immunodeficiency Virus
Feline immunodeficiency virus
Cats
Panthera
Feline Lentiviruses
cats
Acinonyx jubatus
Acinonyx
Lentivirus
Kazakhstan
Mongolia
seroprevalence
Russia
lymph nodes
Seroepidemiologic Studies
spleen
Population
China
Spleen
viruses

Keywords

  • Evolution
  • Felidae
  • FIV
  • Histopathology
  • Pallas' cat

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Brown, M. A., Munkhtsog, B., Troyer, J. L., Ross, S., Sellers, R., Fine, A. E., ... O'Brien, S. J. (2010). Feline immunodeficiency virus (FIV) in wild Pallas' cats. Veterinary Immunology and Immunopathology, 134(1-2), 90-95. https://doi.org/10.1016/j.vetimm.2009.10.014

Feline immunodeficiency virus (FIV) in wild Pallas' cats. / Brown, Meredith A.; Munkhtsog, Bariushaa; Troyer, Jennifer L.; Ross, Steve; Sellers, Rani; Fine, Amanda E.; Swanson, William F.; Roelke, Melody E.; O'Brien, Stephen J.

In: Veterinary Immunology and Immunopathology, Vol. 134, No. 1-2, 15.03.2010, p. 90-95.

Research output: Contribution to journalArticle

Brown, MA, Munkhtsog, B, Troyer, JL, Ross, S, Sellers, R, Fine, AE, Swanson, WF, Roelke, ME & O'Brien, SJ 2010, 'Feline immunodeficiency virus (FIV) in wild Pallas' cats', Veterinary Immunology and Immunopathology, vol. 134, no. 1-2, pp. 90-95. https://doi.org/10.1016/j.vetimm.2009.10.014
Brown MA, Munkhtsog B, Troyer JL, Ross S, Sellers R, Fine AE et al. Feline immunodeficiency virus (FIV) in wild Pallas' cats. Veterinary Immunology and Immunopathology. 2010 Mar 15;134(1-2):90-95. https://doi.org/10.1016/j.vetimm.2009.10.014
Brown, Meredith A. ; Munkhtsog, Bariushaa ; Troyer, Jennifer L. ; Ross, Steve ; Sellers, Rani ; Fine, Amanda E. ; Swanson, William F. ; Roelke, Melody E. ; O'Brien, Stephen J. / Feline immunodeficiency virus (FIV) in wild Pallas' cats. In: Veterinary Immunology and Immunopathology. 2010 ; Vol. 134, No. 1-2. pp. 90-95.
@article{dcc414a957554318bbdf145fdb10f95a,
title = "Feline immunodeficiency virus (FIV) in wild Pallas' cats",
abstract = "Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25{\%} seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host.",
keywords = "Evolution, Felidae, FIV, Histopathology, Pallas' cat",
author = "Brown, {Meredith A.} and Bariushaa Munkhtsog and Troyer, {Jennifer L.} and Steve Ross and Rani Sellers and Fine, {Amanda E.} and Swanson, {William F.} and Roelke, {Melody E.} and O'Brien, {Stephen J.}",
year = "2010",
month = "3",
day = "15",
doi = "10.1016/j.vetimm.2009.10.014",
language = "English (US)",
volume = "134",
pages = "90--95",
journal = "Veterinary Immunology and Immunopathology",
issn = "0165-2427",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Feline immunodeficiency virus (FIV) in wild Pallas' cats

AU - Brown, Meredith A.

AU - Munkhtsog, Bariushaa

AU - Troyer, Jennifer L.

AU - Ross, Steve

AU - Sellers, Rani

AU - Fine, Amanda E.

AU - Swanson, William F.

AU - Roelke, Melody E.

AU - O'Brien, Stephen J.

PY - 2010/3/15

Y1 - 2010/3/15

N2 - Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host.

AB - Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host.

KW - Evolution

KW - Felidae

KW - FIV

KW - Histopathology

KW - Pallas' cat

UR - http://www.scopus.com/inward/record.url?scp=75749144574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749144574&partnerID=8YFLogxK

U2 - 10.1016/j.vetimm.2009.10.014

DO - 10.1016/j.vetimm.2009.10.014

M3 - Article

C2 - 19926144

AN - SCOPUS:75749144574

VL - 134

SP - 90

EP - 95

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

SN - 0165-2427

IS - 1-2

ER -