TY - JOUR
T1 - Feedforward and feedback interactions between visual cortical areas use different population activity patterns
AU - Semedo, João D.
AU - Jasper, Anna I.
AU - Zandvakili, Amin
AU - Krishna, Aravind
AU - Aschner, Amir
AU - Machens, Christian K.
AU - Kohn, Adam
AU - Yu, Byron M.
N1 - Funding Information:
We thank E. Gokcen and A. Motiwala for invaluable discussions and for providing feedback on the manuscript. This work was supported by the Fundação para a Ciência e a Tecnologia graduate scholarship SFRH/BD/52069/2012 (J.D.S.), John and Claire Bertucci Graduate Fellowship (J.D.S.), NIH U01 NS094288 (C.K.M.), Simons Collaboration on the Global Brain 364994 (B.M.Y., A.K.), 543009 (C.K.M.), 543065 (B.M.Y.), 542999 (A.K.), NIH R01 HD071686 (B.M.Y.), NIH CRCNS R01 NS105318 (B.M.Y.), NIH CRCNS R01 MH118929 (B.M.Y.), NIH R01 EB026953 (B.M.Y.), NSF NCS BCS 1533672 and 1734916 (B.M.Y.), NIH EY016774 and EY028626 (A.K.).
Funding Information:
We thank E. Gokcen and A. Motiwala for invaluable discussions and for providing feedback on the manuscript. This work was supported by the Funda??o para a Ci?ncia e a Tecnologia graduate scholarship SFRH/BD/52069/2012 (J.D.S.), John and Claire Bertucci Graduate Fellowship (J.D.S.), NIH U01 NS094288 (C.K.M.), Simons Collaboration on the Global Brain 364994 (B.M.Y., A.K.), 543009 (C.K.M.), 543065 (B.M.Y.), 542999 (A.K.), NIH R01 HD071686 (B.M.Y.), NIH CRCNS R01 NS105318 (B.M.Y.), NIH CRCNS R01 MH118929 (B.M.Y.), NIH R01 EB026953 (B.M.Y.), NSF NCS BCS 1533672 and 1734916 (B.M.Y.), NIH EY016774 and EY028626 (A.K.).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Brain function relies on the coordination of activity across multiple, recurrently connected brain areas. For instance, sensory information encoded in early sensory areas is relayed to, and further processed by, higher cortical areas and then fed back. However, the way in which feedforward and feedback signaling interact with one another is incompletely understood. Here we investigate this question by leveraging simultaneous neuronal population recordings in early and midlevel visual areas (V1–V2 and V1–V4). Using a dimensionality reduction approach, we find that population interactions are feedforward-dominated shortly after stimulus onset and feedback-dominated during spontaneous activity. The population activity patterns most correlated across areas were distinct during feedforward- and feedback-dominated periods. These results suggest that feedforward and feedback signaling rely on separate “channels”, which allows feedback signals to not directly affect activity that is fed forward.
AB - Brain function relies on the coordination of activity across multiple, recurrently connected brain areas. For instance, sensory information encoded in early sensory areas is relayed to, and further processed by, higher cortical areas and then fed back. However, the way in which feedforward and feedback signaling interact with one another is incompletely understood. Here we investigate this question by leveraging simultaneous neuronal population recordings in early and midlevel visual areas (V1–V2 and V1–V4). Using a dimensionality reduction approach, we find that population interactions are feedforward-dominated shortly after stimulus onset and feedback-dominated during spontaneous activity. The population activity patterns most correlated across areas were distinct during feedforward- and feedback-dominated periods. These results suggest that feedforward and feedback signaling rely on separate “channels”, which allows feedback signals to not directly affect activity that is fed forward.
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U2 - 10.1038/s41467-022-28552-w
DO - 10.1038/s41467-022-28552-w
M3 - Article
C2 - 35232956
AN - SCOPUS:85125600547
VL - 13
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 1099
ER -