Fecal microbiota transplantation for recurrent Clostridium difficile infection

Lawrence J. Brandt, Sheela S. Reddy

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

With the increasing prevalence of recurrent/refractory Clostridium difficile infection (CDI), alternative treatments to the standard antibiotic therapies are being sought. One of the more controversial of such alternative treatments is fecal microbiota transplantation (FMT). Although the notion of FMT is foreign - even startling - and not esthetic to most people, the concept has been around for many decades. Its benefit and efficacy dates back >50 years to its use for staphylococcal pseudomembranous colitis, and now FMT is showing a great promise as an inexpensive, safe, and highly efficient treatment for recurrent and refractory CDI. Moreover, with a better understanding of the intricacies of the colonic microbiome and its role in colonic pathophysiology, FMT has the potential to become the standard of care for CDI treatment, and a potential answer to other intestinal disorders in years to come.

Original languageEnglish (US)
Pages (from-to)S159-S167
JournalJournal of clinical gastroenterology
Volume45
Issue numberSUPPL. 3
DOIs
StatePublished - Nov 2011

Keywords

  • fecal bacteriotherapy
  • fecal microbiota transplantation
  • refractory CDI

ASJC Scopus subject areas

  • Gastroenterology

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