Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer

Johannes Schweizer; Peter S. Lu; Charles W. Mahoney; Marthe Berard-Bergery; Minh Ho; Valli Ramasamy; Jon E. Silver; Arnima Bisht; Yassine Labiad; Roger B. Peck; Jeanette Lim; Jose Jeronimo; Roslyn Howard; Patti E. Gravitt; Philip E. Castle

doi:10.1128/JCM.01315-10

Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer

Johannes Schweizer, Peter S. Lu, Charles W. Mahoney, Marthe Berard-Bergery, Minh Ho, Valli Ramasamy, Jon E. Silver, Arnima Bisht, Yassine Labiad, Roger B. Peck, Jeanette Lim, Jose Jeronimo, Roslyn Howard, Patti E. Gravitt, Philip E. Castle

Research output: Contribution to journal › Article › peer-review

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Abstract

In a feasibility study using a prototype, lateral-flow test for human papillomavirus type 16, 18, and/or 45 (HPV16/18/45) E6 oncoproteins, 51 of 75 (68%; 95% confidence interval [95% CI] of 56 to 78%) of HPV16/18/45 DNA-positive specimens from women with a diagnosis of CIN3+ (cervical intraepithelial neoplasia grade 3+ or cervical cancer) tested positive for HPV16/18/45 E6 oncoprotein. None of 16 (95% CI of 0 to 37%) HPV16/18/45 DNA-positive cervical specimens from women with a negative or CIN1 diagnosis tested positive for HPV16/18/45 E6 oncoprotein.

Original language	English (US)
Pages (from-to)	4646-4648
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	48
Issue number	12
DOIs	https://doi.org/10.1128/JCM.01315-10
State	Published - Dec 2010
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/JCM.01315-10

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Schweizer, J., Lu, P. S., Mahoney, C. W., Berard-Bergery, M., Ho, M., Ramasamy, V., Silver, J. E., Bisht, A., Labiad, Y., Peck, R. B., Lim, J., Jeronimo, J., Howard, R., Gravitt, P. E., & Castle, P. E. (2010). Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer. Journal of Clinical Microbiology, 48(12), 4646-4648. https://doi.org/10.1128/JCM.01315-10

Schweizer, J, Lu, PS, Mahoney, CW, Berard-Bergery, M, Ho, M, Ramasamy, V, Silver, JE, Bisht, A, Labiad, Y, Peck, RB, Lim, J, Jeronimo, J, Howard, R, Gravitt, PE & Castle, PE 2010, 'Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer', Journal of Clinical Microbiology, vol. 48, no. 12, pp. 4646-4648. https://doi.org/10.1128/JCM.01315-10

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abstract = "In a feasibility study using a prototype, lateral-flow test for human papillomavirus type 16, 18, and/or 45 (HPV16/18/45) E6 oncoproteins, 51 of 75 (68%; 95% confidence interval [95% CI] of 56 to 78%) of HPV16/18/45 DNA-positive specimens from women with a diagnosis of CIN3+ (cervical intraepithelial neoplasia grade 3+ or cervical cancer) tested positive for HPV16/18/45 E6 oncoprotein. None of 16 (95% CI of 0 to 37%) HPV16/18/45 DNA-positive cervical specimens from women with a negative or CIN1 diagnosis tested positive for HPV16/18/45 E6 oncoprotein.",

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AU - Ho, Minh

AU - Ramasamy, Valli

AU - Silver, Jon E.

AU - Bisht, Arnima

AU - Labiad, Yassine

AU - Peck, Roger B.

AU - Lim, Jeanette

AU - Jeronimo, Jose

AU - Howard, Roslyn

AU - Gravitt, Patti E.

AU - Castle, Philip E.

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Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer

Abstract

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UN SDGs

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