Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer

Johannes Schweizer, Peter S. Lu, Charles W. Mahoney, Marthe Berard-Bergery, Minh Ho, Valli Ramasamy, Jon E. Silver, Arnima Bisht, Yassine Labiad, Roger B. Peck, Jeanette Lim, Jose Jeronimo, Roslyn Howard, Patti E. Gravitt, Philip E. Castle

Research output: Contribution to journalArticle

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Abstract

In a feasibility study using a prototype, lateral-flow test for human papillomavirus type 16, 18, and/or 45 (HPV16/18/45) E6 oncoproteins, 51 of 75 (68%; 95% confidence interval [95% CI] of 56 to 78%) of HPV16/18/45 DNA-positive specimens from women with a diagnosis of CIN3+ (cervical intraepithelial neoplasia grade 3+ or cervical cancer) tested positive for HPV16/18/45 E6 oncoprotein. None of 16 (95% CI of 0 to 37%) HPV16/18/45 DNA-positive cervical specimens from women with a negative or CIN1 diagnosis tested positive for HPV16/18/45 E6 oncoprotein.

Original languageEnglish (US)
Pages (from-to)4646-4648
Number of pages3
JournalJournal of Clinical Microbiology
Volume48
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

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Human papillomavirus 18
Human papillomavirus 16
Oncogene Proteins
Feasibility Studies
Uterine Cervical Neoplasms
Confidence Intervals
Cervical Intraepithelial Neoplasia
DNA

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer. / Schweizer, Johannes; Lu, Peter S.; Mahoney, Charles W.; Berard-Bergery, Marthe; Ho, Minh; Ramasamy, Valli; Silver, Jon E.; Bisht, Arnima; Labiad, Yassine; Peck, Roger B.; Lim, Jeanette; Jeronimo, Jose; Howard, Roslyn; Gravitt, Patti E.; Castle, Philip E.

In: Journal of Clinical Microbiology, Vol. 48, No. 12, 12.2010, p. 4646-4648.

Research output: Contribution to journalArticle

Schweizer, J, Lu, PS, Mahoney, CW, Berard-Bergery, M, Ho, M, Ramasamy, V, Silver, JE, Bisht, A, Labiad, Y, Peck, RB, Lim, J, Jeronimo, J, Howard, R, Gravitt, PE & Castle, PE 2010, 'Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer', Journal of Clinical Microbiology, vol. 48, no. 12, pp. 4646-4648. https://doi.org/10.1128/JCM.01315-10
Schweizer, Johannes ; Lu, Peter S. ; Mahoney, Charles W. ; Berard-Bergery, Marthe ; Ho, Minh ; Ramasamy, Valli ; Silver, Jon E. ; Bisht, Arnima ; Labiad, Yassine ; Peck, Roger B. ; Lim, Jeanette ; Jeronimo, Jose ; Howard, Roslyn ; Gravitt, Patti E. ; Castle, Philip E. / Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer. In: Journal of Clinical Microbiology. 2010 ; Vol. 48, No. 12. pp. 4646-4648.
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