Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer

Johannes Schweizer, Peter S. Lu, Charles W. Mahoney, Marthe Berard-Bergery, Minh Ho, Valli Ramasamy, Jon E. Silver, Arnima Bisht, Yassine Labiad, Roger B. Peck, Jeanette Lim, Jose Jeronimo, Roslyn Howard, Patti E. Gravitt, Philip E. Castle

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Abstract

In a feasibility study using a prototype, lateral-flow test for human papillomavirus type 16, 18, and/or 45 (HPV16/18/45) E6 oncoproteins, 51 of 75 (68%; 95% confidence interval [95% CI] of 56 to 78%) of HPV16/18/45 DNA-positive specimens from women with a diagnosis of CIN3+ (cervical intraepithelial neoplasia grade 3+ or cervical cancer) tested positive for HPV16/18/45 E6 oncoprotein. None of 16 (95% CI of 0 to 37%) HPV16/18/45 DNA-positive cervical specimens from women with a negative or CIN1 diagnosis tested positive for HPV16/18/45 E6 oncoprotein.

Original languageEnglish (US)
Pages (from-to)4646-4648
Number of pages3
JournalJournal of Clinical Microbiology
Volume48
Issue number12
DOIs
StatePublished - Dec 1 2010

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ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Schweizer, J., Lu, P. S., Mahoney, C. W., Berard-Bergery, M., Ho, M., Ramasamy, V., Silver, J. E., Bisht, A., Labiad, Y., Peck, R. B., Lim, J., Jeronimo, J., Howard, R., Gravitt, P. E., & Castle, P. E. (2010). Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer. Journal of Clinical Microbiology, 48(12), 4646-4648. https://doi.org/10.1128/JCM.01315-10