Feasibility of 64-slice gadolinium-enhanced cardiac CT for the evaluation of obstructive coronary artery disease

Patricia Carrascosa, Carlos Capuñay, Alejandro Deviggiano, Marcelo Bettinotti, Alejandro Goldsmit, Carlos Tajer, Jorge Carrascosa, Mario J. Garcia

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To assess the feasibility of gadolinium-enhanced 64-slice cardiac CT (CCT) for the diagnosis of obstructive coronary artery disease. Design: Comparative prospective study. Setting: Outpatient Imaging Diagnostic Centre, Diagnóstico Maipú, Buenos Aires, Argentina. Patients: Twenty patients with suspected coronary artery disease. Interventions: Gadolinium-enhanced 64-slice CCT was performed before invasive coronary angiography (ICA). Main outcome measures: The feasibility of gadolinium-enhanced 64-slice CCT for detection of obstructive coronary artery disease (>50% diameter reduction) was evaluated, using ICA as the 'gold standard'. Mean lumen attenuation, non-calcified and calcified plaques densities were correlated between gadolinium-enhanced CCT studies and iodine-enhanced CCT studies of a control group. Renal function was strictly monitored. Results: Gadolinium-enhanced CCT demonstrated adequate visualisation of 283/289 coronary segments that were evaluable by ICA, 31 of which had >50% luminal stenosis. In per-segment analysis, gadolinium-enhanced CCT showed a sensitivity of 90.3%, specificity of 96.8%, positive predictive value of 77.8% and negative predictive value of 98.8%. The agreement of coronary stenosis between multidetector CT (MDCT) and ICA was 94.1% (272/289). The mean lumen attenuation, non-calcified and calcified plaques densities in gadolinium-enhanced CCT studies were 140.1 Hounsfield units (HU), 51.1 HU and 523.6 HU, whereas in iodine-enhanced CCT studies the values were 354.1 HU, 101.0 HU and 778.5 HU, respectively (p < 0.001). Conclusion: Gadolinium-enhanced CCT is a feasible alternative for patients with severe contraindications to iodinated contrast agents referred for MDCT coronary angiography.

Original languageEnglish (US)
Pages (from-to)1543-1549
Number of pages7
JournalHeart
Volume96
Issue number19
DOIs
StatePublished - Oct 2010
Externally publishedYes

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Gadolinium
Coronary Artery Disease
Coronary Angiography
Iodine
Coronary Stenosis
Argentina
Diagnostic Imaging
Contrast Media
Pathologic Constriction
Outpatients
Outcome Assessment (Health Care)
Prospective Studies
Kidney
Sensitivity and Specificity
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Carrascosa, P., Capuñay, C., Deviggiano, A., Bettinotti, M., Goldsmit, A., Tajer, C., ... Garcia, M. J. (2010). Feasibility of 64-slice gadolinium-enhanced cardiac CT for the evaluation of obstructive coronary artery disease. Heart, 96(19), 1543-1549. https://doi.org/10.1136/hrt.2009.183699

Feasibility of 64-slice gadolinium-enhanced cardiac CT for the evaluation of obstructive coronary artery disease. / Carrascosa, Patricia; Capuñay, Carlos; Deviggiano, Alejandro; Bettinotti, Marcelo; Goldsmit, Alejandro; Tajer, Carlos; Carrascosa, Jorge; Garcia, Mario J.

In: Heart, Vol. 96, No. 19, 10.2010, p. 1543-1549.

Research output: Contribution to journalArticle

Carrascosa, P, Capuñay, C, Deviggiano, A, Bettinotti, M, Goldsmit, A, Tajer, C, Carrascosa, J & Garcia, MJ 2010, 'Feasibility of 64-slice gadolinium-enhanced cardiac CT for the evaluation of obstructive coronary artery disease', Heart, vol. 96, no. 19, pp. 1543-1549. https://doi.org/10.1136/hrt.2009.183699
Carrascosa P, Capuñay C, Deviggiano A, Bettinotti M, Goldsmit A, Tajer C et al. Feasibility of 64-slice gadolinium-enhanced cardiac CT for the evaluation of obstructive coronary artery disease. Heart. 2010 Oct;96(19):1543-1549. https://doi.org/10.1136/hrt.2009.183699
Carrascosa, Patricia ; Capuñay, Carlos ; Deviggiano, Alejandro ; Bettinotti, Marcelo ; Goldsmit, Alejandro ; Tajer, Carlos ; Carrascosa, Jorge ; Garcia, Mario J. / Feasibility of 64-slice gadolinium-enhanced cardiac CT for the evaluation of obstructive coronary artery disease. In: Heart. 2010 ; Vol. 96, No. 19. pp. 1543-1549.
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abstract = "Objective: To assess the feasibility of gadolinium-enhanced 64-slice cardiac CT (CCT) for the diagnosis of obstructive coronary artery disease. Design: Comparative prospective study. Setting: Outpatient Imaging Diagnostic Centre, Diagn{\'o}stico Maip{\'u}, Buenos Aires, Argentina. Patients: Twenty patients with suspected coronary artery disease. Interventions: Gadolinium-enhanced 64-slice CCT was performed before invasive coronary angiography (ICA). Main outcome measures: The feasibility of gadolinium-enhanced 64-slice CCT for detection of obstructive coronary artery disease (>50{\%} diameter reduction) was evaluated, using ICA as the 'gold standard'. Mean lumen attenuation, non-calcified and calcified plaques densities were correlated between gadolinium-enhanced CCT studies and iodine-enhanced CCT studies of a control group. Renal function was strictly monitored. Results: Gadolinium-enhanced CCT demonstrated adequate visualisation of 283/289 coronary segments that were evaluable by ICA, 31 of which had >50{\%} luminal stenosis. In per-segment analysis, gadolinium-enhanced CCT showed a sensitivity of 90.3{\%}, specificity of 96.8{\%}, positive predictive value of 77.8{\%} and negative predictive value of 98.8{\%}. The agreement of coronary stenosis between multidetector CT (MDCT) and ICA was 94.1{\%} (272/289). The mean lumen attenuation, non-calcified and calcified plaques densities in gadolinium-enhanced CCT studies were 140.1 Hounsfield units (HU), 51.1 HU and 523.6 HU, whereas in iodine-enhanced CCT studies the values were 354.1 HU, 101.0 HU and 778.5 HU, respectively (p < 0.001). Conclusion: Gadolinium-enhanced CCT is a feasible alternative for patients with severe contraindications to iodinated contrast agents referred for MDCT coronary angiography.",
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AU - Bettinotti, Marcelo

AU - Goldsmit, Alejandro

AU - Tajer, Carlos

AU - Carrascosa, Jorge

AU - Garcia, Mario J.

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N2 - Objective: To assess the feasibility of gadolinium-enhanced 64-slice cardiac CT (CCT) for the diagnosis of obstructive coronary artery disease. Design: Comparative prospective study. Setting: Outpatient Imaging Diagnostic Centre, Diagnóstico Maipú, Buenos Aires, Argentina. Patients: Twenty patients with suspected coronary artery disease. Interventions: Gadolinium-enhanced 64-slice CCT was performed before invasive coronary angiography (ICA). Main outcome measures: The feasibility of gadolinium-enhanced 64-slice CCT for detection of obstructive coronary artery disease (>50% diameter reduction) was evaluated, using ICA as the 'gold standard'. Mean lumen attenuation, non-calcified and calcified plaques densities were correlated between gadolinium-enhanced CCT studies and iodine-enhanced CCT studies of a control group. Renal function was strictly monitored. Results: Gadolinium-enhanced CCT demonstrated adequate visualisation of 283/289 coronary segments that were evaluable by ICA, 31 of which had >50% luminal stenosis. In per-segment analysis, gadolinium-enhanced CCT showed a sensitivity of 90.3%, specificity of 96.8%, positive predictive value of 77.8% and negative predictive value of 98.8%. The agreement of coronary stenosis between multidetector CT (MDCT) and ICA was 94.1% (272/289). The mean lumen attenuation, non-calcified and calcified plaques densities in gadolinium-enhanced CCT studies were 140.1 Hounsfield units (HU), 51.1 HU and 523.6 HU, whereas in iodine-enhanced CCT studies the values were 354.1 HU, 101.0 HU and 778.5 HU, respectively (p < 0.001). Conclusion: Gadolinium-enhanced CCT is a feasible alternative for patients with severe contraindications to iodinated contrast agents referred for MDCT coronary angiography.

AB - Objective: To assess the feasibility of gadolinium-enhanced 64-slice cardiac CT (CCT) for the diagnosis of obstructive coronary artery disease. Design: Comparative prospective study. Setting: Outpatient Imaging Diagnostic Centre, Diagnóstico Maipú, Buenos Aires, Argentina. Patients: Twenty patients with suspected coronary artery disease. Interventions: Gadolinium-enhanced 64-slice CCT was performed before invasive coronary angiography (ICA). Main outcome measures: The feasibility of gadolinium-enhanced 64-slice CCT for detection of obstructive coronary artery disease (>50% diameter reduction) was evaluated, using ICA as the 'gold standard'. Mean lumen attenuation, non-calcified and calcified plaques densities were correlated between gadolinium-enhanced CCT studies and iodine-enhanced CCT studies of a control group. Renal function was strictly monitored. Results: Gadolinium-enhanced CCT demonstrated adequate visualisation of 283/289 coronary segments that were evaluable by ICA, 31 of which had >50% luminal stenosis. In per-segment analysis, gadolinium-enhanced CCT showed a sensitivity of 90.3%, specificity of 96.8%, positive predictive value of 77.8% and negative predictive value of 98.8%. The agreement of coronary stenosis between multidetector CT (MDCT) and ICA was 94.1% (272/289). The mean lumen attenuation, non-calcified and calcified plaques densities in gadolinium-enhanced CCT studies were 140.1 Hounsfield units (HU), 51.1 HU and 523.6 HU, whereas in iodine-enhanced CCT studies the values were 354.1 HU, 101.0 HU and 778.5 HU, respectively (p < 0.001). Conclusion: Gadolinium-enhanced CCT is a feasible alternative for patients with severe contraindications to iodinated contrast agents referred for MDCT coronary angiography.

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