TY - JOUR
T1 - Feasibility and safety of uninterrupted periprocedural apixaban administration in patients undergoing radiofrequency catheter ablation for atrial fibrillation
T2 - Results from a multicenter study
AU - Di Biase, Luigi
AU - Lakkireddy, Dhanujaya
AU - Trivedi, Chintan
AU - Deneke, Thomas
AU - Martinek, Martin
AU - Mohanty, Sanghamitra
AU - Mohanty, Prasant
AU - Prakash, Sameer
AU - Bai, Rong
AU - Reddy, Madhu
AU - Gianni, Carola
AU - Horton, Rodney
AU - Bailey, Shane
AU - Sigmund, Elisabeth
AU - Derndorfer, Michael
AU - Schade, Anja
AU - Mueller, Patrick
AU - Szoelloes, Atilla
AU - Sanchez, Javier
AU - Al-Ahmad, Amin
AU - Hranitzky, Patrick
AU - Gallinghouse, G. Joseph
AU - Hongo, Richard H.
AU - Beheiry, Salwa
AU - Pürerfellner, Helmut
AU - Burkhardt, J. David
AU - Natale, Andrea
N1 - Publisher Copyright:
© 2015 Heart Rhythm Society.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Background Periprocedural anticoagulation management with uninterrupted warfarin and a "therapeutic" international normalized ratio is the best approach for reducing both thromboembolic and bleeding complications in the setting of catheter ablation for atrial fibrillation (AF). Objective The purpose of this study was to evaluate the safety and feasibility of uninterrupted apixaban in this setting. Methods This was a prospective multicenter registry of AF patients undergoing radiofrequency catheter ablation at 4 institutions in United States and Europe with uninterrupted apixaban. These patients were compared with an equal number of patients, matched for age, gender, and type of AF, undergoing AF ablation on uninterrupted warfarin. The apixaban group was comprised of consecutive patients who had taken their last dose of apixaban the morning of the procedure. A subset of 29 patients in the apixaban group underwent diffusion magnetic resonance imaging (dMRI) to detect silent cerebral ischemia. Results A total of 400 patients (200 patients in each group) were included in the study. The average age was 65.9 ± 9.9 years, 286 (71.5%) were male, and 334 (83.5%) had nonparoxysmal AF. There were no statistical differences with regard to major complications (1% vs 0.5%, P = 1), minor complications (3.5% vs 2.5%, P =.56), or total bleeding complications (4.5% vs 3%, P =.43) between the apixaban and warfarin groups. There were no symptomatic thromboembolic complications. All dMRIs were negative for "new" silent cerebral ischemia in the apixaban group. Conclusion Uninterrupted apixaban administration in patients undergoing AF ablation seems to be feasible and effective in preventing clinical and silent thromboembolic events without increasing the risk of major bleeding.
AB - Background Periprocedural anticoagulation management with uninterrupted warfarin and a "therapeutic" international normalized ratio is the best approach for reducing both thromboembolic and bleeding complications in the setting of catheter ablation for atrial fibrillation (AF). Objective The purpose of this study was to evaluate the safety and feasibility of uninterrupted apixaban in this setting. Methods This was a prospective multicenter registry of AF patients undergoing radiofrequency catheter ablation at 4 institutions in United States and Europe with uninterrupted apixaban. These patients were compared with an equal number of patients, matched for age, gender, and type of AF, undergoing AF ablation on uninterrupted warfarin. The apixaban group was comprised of consecutive patients who had taken their last dose of apixaban the morning of the procedure. A subset of 29 patients in the apixaban group underwent diffusion magnetic resonance imaging (dMRI) to detect silent cerebral ischemia. Results A total of 400 patients (200 patients in each group) were included in the study. The average age was 65.9 ± 9.9 years, 286 (71.5%) were male, and 334 (83.5%) had nonparoxysmal AF. There were no statistical differences with regard to major complications (1% vs 0.5%, P = 1), minor complications (3.5% vs 2.5%, P =.56), or total bleeding complications (4.5% vs 3%, P =.43) between the apixaban and warfarin groups. There were no symptomatic thromboembolic complications. All dMRIs were negative for "new" silent cerebral ischemia in the apixaban group. Conclusion Uninterrupted apixaban administration in patients undergoing AF ablation seems to be feasible and effective in preventing clinical and silent thromboembolic events without increasing the risk of major bleeding.
KW - Anticoagulant
KW - Atrial fibrillation
KW - Catheterablation
KW - Silentthromboemboliclesion
KW - Stroke
KW - Warfarin
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U2 - 10.1016/j.hrthm.2015.02.028
DO - 10.1016/j.hrthm.2015.02.028
M3 - Article
C2 - 25728754
AN - SCOPUS:84930383050
SN - 1547-5271
VL - 12
SP - 1162
EP - 1168
JO - Heart Rhythm
JF - Heart Rhythm
IS - 6
ER -